Thandavarayan, Rajarajan

Publications

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selected publications

Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome. Cell cycle (Georgetown, Tex.). 2019 Academic Article GET IT
Times cited: 20
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema. Disease models & mechanisms. 2019 Academic Article GET IT
Times cited: 28
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 47
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. PloS one. 2018 Academic Article GET IT
Times cited: 13
In search of suitable extraction technique for large scale commercial production of bioactive fraction for the treatment of diabetes: The case Diospyros melanoxylon Roxb. Journal of traditional and complementary medicine. 2018 Academic Article GET IT
Times cited: 15
Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming. Antioxidants & redox signaling. 2018 Information Resource GET IT
Times cited: 11
Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography. PloS one. 2018 Academic Article GET IT
Times cited: 19
Transflammation: Innate immune signaling in nuclear reprogramming. Advanced drug delivery reviews. 2017 Information Resource GET IT
Times cited: 12
Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges. Drug discovery today. 2017 Information Resource GET IT
Times cited: 37
Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus. The international journal of biochemistry & cell biology. 2017 Academic Article GET IT
Times cited: 9
Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder. Translational psychiatry. 2016 Information Resource GET IT
Times cited: 24
MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes. Scientific reports. 2016 Academic Article GET IT
Times cited: 72
The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging. Ageing research reviews. 2016 Information Resource GET IT
Times cited: 19
ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes. Journal of diabetes research. 2016 Academic Article GET IT
Times cited: 15
Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity. PloS one. 2016 Academic Article GET IT
Times cited: 25
Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy. Nutrition (Burbank, Los Angeles County, Calif.). 2016 Information Resource GET IT
Times cited: 26
Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy. BioFactors (Oxford, England). 2016 Academic Article GET IT
Times cited: 3
Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice. Epilepsy research. 2016 Academic Article GET IT
Times cited: 2
Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion. Cell biochemistry and function. 2016 Academic Article GET IT
Times cited: 3
Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats. Cytokine. 2016 Academic Article GET IT
Times cited: 34
Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model. Experimental dermatology. 2016 Article GET IT
Times cited: 18
Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice. BioFactors (Oxford, England). 2016 Academic Article GET IT
Times cited: 21
Hypothalamic glucagon signaling in fasting hypoglycemia. Life sciences. 2016 Academic Article GET IT
Times cited: 2
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. PloS one. 2016 Academic Article GET IT
Times cited: 62
Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?. Alcoholism, clinical and experimental research. 2016 Information Resource GET IT
Times cited: 16
Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease. Drug discovery today. 2016 Information Resource GET IT
Times cited: 41
Editorial Commentary: miRNA a tiny genetic tool: Key to the puzzle of cardiovascular disease. Trends in cardiovascular medicine. 2016 Editorial Article GET IT
Times cited: 2
Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis. Drug discovery today. 2016 Information Resource GET IT
Times cited: 54
Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?. Drug discovery today. 2016 Information Resource GET IT
Times cited: 21
MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. Biochemical and biophysical research communications. 2016 Academic Article GET IT
Times cited: 135
Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377. Journal of the American College of Cardiology. 2015 Academic Article GET IT
Times cited: 67
Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes. Cellular signalling. 2015 Academic Article GET IT
Times cited: 17
Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression. PloS one. 2015 Academic Article GET IT
Times cited: 65
Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis. International immunopharmacology. 2015 Academic Article GET IT
Times cited: 12
Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice. Evidence-based complementary and alternative medicine : eCAM. 2015 Academic Article GET IT
Times cited: 6
Toki-shakuyaku-san, a Japanese kampo medicine, reduces colon inflammation in a mouse model of acute colitis. International immunopharmacology. 2015 Academic Article GET IT
Times cited: 11
Depletion of cardiac 14-3-3η protein adversely influences pathologic cardiac remodeling during myocardial infarction after coronary artery ligation in mice. International journal of cardiology. 2015 Academic Article GET IT
Times cited: 12
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing. Experimental dermatology. 2015 Academic Article GET IT
Times cited: 40
Angiotensin receptor blockers: Focus on cardiac and renal injury. Trends in cardiovascular medicine. 2015 Information Resource GET IT
Times cited: 17
Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation. International immunopharmacology. 2015 Academic Article GET IT
Times cited: 33
Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Academic Article GET IT
Times cited: 34
Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium. Cytokine. 2015 Academic Article GET IT
Times cited: 16
Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Experimental dermatology. 2015 Academic Article GET IT
Times cited: 57
Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy. Cellular signalling. 2015 Academic Article GET IT
Times cited: 15
Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PloS one. 2015 Academic Article GET IT
Times cited: 113
Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration. Trends in cardiovascular medicine. 2015 Editorial Article GET IT
RNA-stabilizing proteins as molecular targets in cardiovascular pathologies. Trends in cardiovascular medicine. 2015 Information Resource GET IT
Times cited: 24
Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats. Free radical research. 2015 Academic Article GET IT
Times cited: 67
Pruni cortex ameliorates skin inflammation possibly through HMGB1-NFκB pathway in house dust mite induced atopic dermatitis NC/Nga transgenic mice. Journal of clinical biochemistry and nutrition. 2015 Academic Article GET IT
Times cited: 13
Myocardial 14-3-3η protein protects against mitochondria mediated apoptosis. Cellular signalling. 2015 Academic Article GET IT
Times cited: 22
Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. International immunopharmacology. 2014 Academic Article GET IT
Times cited: 45
Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration. International journal of molecular sciences. 2014 Information Resource GET IT
Times cited: 40
Fasting mediated increase in p-BAD(ser155) and p-AKT(ser473) in the prefrontal cortex of mice. Neuroscience letters. 2014 Academic Article GET IT
Times cited: 2
Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy. Experimental and molecular pathology. 2014 Academic Article GET IT
Times cited: 13
Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK-mediated apoptosis. Cardiovascular therapeutics. 2013 Academic Article GET IT
Times cited: 19
Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats. International immunopharmacology. 2013 Academic Article GET IT
Times cited: 24
Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Medical molecular morphology. 2012 Academic Article GET IT
Times cited: 12
Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy. Journal of cellular and molecular medicine. 2012 Academic Article GET IT
Times cited: 28
Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2012 Academic Article GET IT
Times cited: 105
Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. Experimental and molecular pathology. 2012 Academic Article GET IT
Times cited: 21
Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats. Journal of clinical biochemistry and nutrition. 2012 Academic Article GET IT
Times cited: 24
Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling. Free radical research. 2012 Academic Article GET IT
Times cited: 36
Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice. Free radical research. 2012 Academic Article GET IT
Times cited: 38
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-ĸB signaling pathways after streptozotocin-induced diabetes mellitus. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011 Academic Article GET IT
Times cited: 46
Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochemical pharmacology. 2011 Academic Article GET IT
Times cited: 33
Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Toxicology. 2011 Academic Article GET IT
Times cited: 23
Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats. Journal of clinical biochemistry and nutrition. 2011 Academic Article GET IT
Times cited: 25
Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2011 Academic Article GET IT
Times cited: 63
Diabetic cardiomyopathy and oxidative stress: role of antioxidants. Cardiovascular & hematological agents in medicinal chemistry. 2011 Information Resource GET IT
Times cited: 17
Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats. Molecular nutrition & food research. 2011 Academic Article GET IT
Times cited: 93
Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis. Free radical research. 2011 Academic Article GET IT
Times cited: 22
Ocimum sanctum Linn. leaf extracts inhibit acetylcholinesterase and improve cognition in rats with experimentally induced dementia. Journal of medicinal food. 2011 Academic Article GET IT
Times cited: 27
Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozotocin-induced diabetic mice. Molecular and cellular endocrinology. 2011 Academic Article GET IT
Times cited: 39
Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38α mitogen-activated protein kinase mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011 Academic Article GET IT
Times cited: 30
Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutrition & metabolism. 2011 Academic Article GET IT
Times cited: 193
Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom. Food & function. 2011 Academic Article GET IT
Times cited: 26
Regulation of inflammation and myocardial fibrosis in experimental autoimmune myocarditis. Inflammation & allergy drug targets. 2011 Information Resource GET IT
Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Free radical research. 2011 Academic Article GET IT
Times cited: 32
Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice. Journal of medicinal food. 2011 Academic Article GET IT
Times cited: 16
Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy. ISRN pharmacology. 2011 Academic Article GET IT
Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action. Free radical research. 2011 Academic Article GET IT
Times cited: 64
Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis. International journal of biological sciences. 2011 Academic Article GET IT
Times cited: 62
Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis. Biological & pharmaceutical bulletin. 2011 Academic Article GET IT
Times cited: 22
Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats. Free radical research. 2010 Academic Article GET IT
Times cited: 12
Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy. Current cardiology reviews. 2010 Academic Article GET IT
Times cited: 75
Effect of telmisartan in limiting the cardiotoxic effect of daunorubicin in rats. The Journal of pharmacy and pharmacology. 2010 Academic Article GET IT
Times cited: 23
Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. Toxicology. 2010 Academic Article GET IT
Times cited: 18
Beneficial effects of olmesartan, an angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy. Experimental biology and medicine (Maywood, N.J.). 2010 Academic Article GET IT
Times cited: 15
Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2010 Academic Article GET IT
Times cited: 12
The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. Free radical research. 2010 Academic Article GET IT
Times cited: 36
Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2010 Academic Article GET IT
Times cited: 13
Arginine vasopressin receptor antagonists (vaptans): pharmacological tools and potential therapeutic agents. Drug discovery today. 2010 Information Resource GET IT
Times cited: 23
Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice. Free radical biology & medicine. 2010 Academic Article GET IT
Times cited: 38
14-3-3 protein protects against cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis in experimental diabetes. Journal of pharmacological sciences. 2010 Academic Article GET IT
Times cited: 31
Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy. Hypertension research : official journal of the Japanese Society of Hypertension. 2010 Academic Article GET IT
Times cited: 37
Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats. Toxicology. 2010 Academic Article GET IT
Times cited: 48
Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy. Acta physiologica Hungarica. 2009 Information Resource GET IT
Times cited: 19
Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats. Biological & pharmaceutical bulletin. 2009 Academic Article GET IT
Times cited: 34
Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. American journal of physiology. Heart and circulatory physiology. 2009 Academic Article GET IT
Times cited: 80
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochemical pharmacology. 2008 Academic Article GET IT
Times cited: 66
Comparative effects of torasemide and furosemide in rats with heart failure. Biochemical pharmacology. 2007 Academic Article GET IT
Times cited: 36

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Background

education and training

Ph.D., Niigata University of Pharmacy and Applied Life Sciences (Japan) 2010
M.Pharm., The Tamil Nadu Dr.M.G.R. Medical University (India) 2002
B.Pharm., The Tamil Nadu Dr.M.G.R. Medical University (India) 2000

Contact

full name

Rajarajan Thandavarayan

VIVO Weill Cornell Medical College

Rajarajan Thandavarayan Assistant Professor of Cardiology Research in Medicine

Publications

selected publications

Background

education and training

Contact

full name