Upadhyay, Saurabh

Publications

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Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Academic Article GET IT
As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Academic Article GET IT
Times cited: 1
HTS-Oracle: Experimentally validated AI-enabled prioritization for generalizable small molecule hit discovery. bioRxiv : the preprint server for biology. 2025 Article GET IT
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. Journal of medicinal chemistry. 2025 Academic Article GET IT
Times cited: 1
Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. ACS omega. 2025 Academic Article GET IT
Times cited: 1
Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 Costimulation. bioRxiv : the preprint server for biology. 2025 Article GET IT
Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models. European journal of medicinal chemistry. 2025 Academic Article GET IT
Times cited: 6
Designing immunity with cytokines: A logic-based framework for programmable CAR therapies. Cytokine & growth factor reviews. 2025 Information Resource GET IT
Times cited: 7
Wiring and rewiring PANoptosis: Molecular vulnerabilities for targeting inflammatory cell death in human disease. Cytokine & growth factor reviews. 2025 Information Resource GET IT
Times cited: 8
As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition. bioRxiv : the preprint server for biology. 2025 Article GET IT
Phenotypic and targeted drug discovery in immune therapeutics: challenges, opportunities, and future directions. RSC advances. 2025 Information Resource GET IT
Times cited: 2
An Optimized Enzyme-Coupled Spectrophotometric Method for Measuring Pyruvate Kinase Kinetics. Bio-protocol. 2025 Academic Article GET IT
Times cited: 1
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders. SLAS discovery : advancing life sciences R & D. 2025 Academic Article GET IT
Times cited: 7
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation. bioRxiv : the preprint server for biology. 2025 Article GET IT
HTS-Oracle: A Retrainable AI Platform for High-Confidence Hit Identification Across Difficult-to-Drug Targets. bioRxiv : the preprint server for biology. 2025 Article GET IT
Small Molecule-Based Blockade of CD28 Suppresses T Cell Costimulation Across Cellular and Mucosal Co-culture Models. bioRxiv : the preprint server for biology. 2025 Article GET IT
Surface Plasmon Resonance (SPR)-Based Workflow for High-Throughput Discovery of CD28-Targeted Small Molecules. bioRxiv : the preprint server for biology. 2025 Article GET IT
CD28 and ICOS in immune regulation: Structural insights and therapeutic targeting. Bioorganic & medicinal chemistry letters. 2025 Information Resource GET IT
Times cited: 5
Impact of Cancer-Associated PKM2 Mutations on Enzyme Activity and Allosteric Regulation: Structural and Functional Insights into Metabolic Reprogramming. Biochemistry. 2025 Academic Article GET IT
Times cited: 14
Novel prospects in targeting neurodegenerative disorders via autophagy. European journal of pharmacology. 2024 Information Resource GET IT
Times cited: 10
Exploring the diverse role of pyruvate kinase M2 in cancer: Navigating beyond glycolysis and the Warburg effect. Biochimica et biophysica acta. Reviews on cancer. 2024 Information Resource GET IT
Times cited: 47
Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase. International journal of biological macromolecules. 2023 Academic Article GET IT
Times cited: 14
Screening and evaluation of approved drugs as inhibitors of main protease of SARS-CoV-2. International journal of biological macromolecules. 2020 Academic Article GET IT
Times cited: 54
Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease. Phytotherapy research : PTR. 2020 Academic Article GET IT
Times cited: 53

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Research

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Funding awarded

Small molecule inhibitors of CAPON-induced tau aggregation awarded by National Institute on Aging Key Personnel 2024 - 2027

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Background

education and training

Ph.D., Indian Institute of Technology (India) 2024
M.Sc., Jamia Millia Islamia (India) 2017
B.Sc., University of Delhi (India) 2015

Contact

full name

Saurabh Upadhyay

primary email

sau4005@med.cornell.edu

VIVO Weill Cornell Medical College

Saurabh Upadhyay Postdoctoral Associate in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email