selected publications
- DAXX is associated with early recurrence of pancreatic neuroendocrine tumors after R0 resection. Surgery. 2024 Academic Article GET IT
- An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study- Identified Diabetes Genes and Drug Discovery. 2024 GET IT
- Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders. 2024 GET IT
- The Precise Basecalling of Short-Read Nanopore Sequencing. 2024 GET IT
- Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection. Cell stem cell. 2024 Academic Article GET IT
- Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection. 2024 GET IT
- Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h. Diabetologia. 2024 Academic Article GET IT
- Untangling the genetics of beta cell dysfunction and death in type 1 diabetes. Molecular metabolism. 2024 Review GET IT
- Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. 2024 GET IT
- Author Correction: Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. 2024 GET IT
- The efficacy of coaxial percutaneous iodine-125 seed implantation combined with arterial infusion chemotherapy for advanced pancreatic cancer: a randomized clinical trial. International journal of radiation biology. 2024 Academic Article GET IT
- ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels. Circulation. 2024 Academic Article GET IT
- SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell stem cell. 2024 Academic Article GET IT
- Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nature biotechnology. 2024 Academic Article GET IT
- Genetic Alterations of NF-κB and Its Regulators: A Rich Platform to Advance Colorectal Cancer Diagnosis and Treatment. International journal of molecular sciences. 2023 Review GET IT
- A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS. Cell stem cell. 2023 Academic Article GET IT
- A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. Journal of molecular cell biology. 2023 Academic Article GET IT
- Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nature chemical biology. 2023 Academic Article GET IT
- An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals. 2023 GET IT
- Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells. Cell metabolism. 2023 Academic Article GET IT
- Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes. Stem cell research & therapy. 2023 Academic Article GET IT
- Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
- Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023 Academic Article GET IT
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Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.
Cell stem cell.
2023
Academic Article
GET IT
Times cited: 1 - Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation. Cell stem cell. 2023 Review GET IT
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Genipin Crosslinks the Extracellular Matrix to Rescue Developmental and Degenerative Defects, and Accelerates Regeneration of Peripheral Neurons.
2023
GET IT
Times cited: 43 - A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
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A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.
Nature cell biology.
2023
Academic Article
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Times cited: 9 - Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. Science (New York, N.Y.). 2022 Academic Article GET IT
- Selective targeting of visceral adiposity by polycation nanomedicine. Nature nanotechnology. 2022 Academic Article GET IT
- Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling. 2022 Academic Article GET IT
- Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path. ACS bio & med chem Au. 2022 Academic Article GET IT
- A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell stem cell. 2022 Academic Article GET IT
- Druggable targets and therapeutic development for COVID-19. Frontiers in chemistry. 2022 Review GET IT
- Organoids as tools for fundamental discovery and translation-A Keystone Symposia report. Annals of the New York Academy of Sciences. 2022 Academic Article GET IT
- Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis. Cell stem cell. 2022 Comment GET IT
- Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy. iScience. 2022 Academic Article GET IT
- Human organoid models to study SARS-CoV-2 infection. Nature methods. 2022 Review GET IT
- Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances. 2022 Academic Article GET IT
- A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
- SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circulation research. 2022 Academic Article GET IT
- Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation. Cell reports. 2021 Academic Article GET IT
- An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell reports. 2021 Academic Article GET IT
- Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry. Molecular medicine (Cambridge, Mass.). 2021 Academic Article GET IT
- Retraction Note to: Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells. Molecular biotechnology. 2021 Article GET IT
- Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem cell reports. 2021 Academic Article GET IT
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SARS-CoV-2 infection induces beta cell transdifferentiation.
Cell metabolism.
2021
Academic Article
GET IT
Times cited: 132 - The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3-beta signaling. The Journal of biological chemistry. 2021 Academic Article GET IT
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An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts.
Circulation research.
2021
Academic Article
GET IT
Times cited: 45 - Phenotypic technologies in stem cell biology. Cell chemical biology. 2021 Information Resource GET IT
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Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery.
Stem cell research.
2021
Academic Article
GET IT
Times cited: 12 -
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Nature.
2020
Academic Article
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Times cited: 367 -
Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
EBioMedicine.
2020
Academic Article
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Times cited: 20 -
Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids.
Journal of molecular cell biology.
2020
Information Resource
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Times cited: 7 -
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes.
Cell stem cell.
2020
Academic Article
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Times cited: 48 -
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Cell stem cell.
2020
Academic Article
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Times cited: 495 -
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity.
Cardiovascular research.
2020
Academic Article
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Times cited: 15 - Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics. Journal of molecular cell biology. 2019 Article GET IT
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Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells.
Nature communications.
2019
Academic Article
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Times cited: 25 -
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Scientific reports.
2019
Academic Article
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Times cited: 14 -
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.
Nature genetics.
2019
Academic Article
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Times cited: 80 -
Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β.
Cell chemical biology.
2019
Academic Article
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Times cited: 18 -
Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.
Neuron.
2019
Academic Article
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Times cited: 55 -
Screening-Based Chemical Approaches to Unravel Stem Cell Biology.
Stem cell reports.
2018
Information Resource
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Times cited: 9 -
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.
Nature communications.
2018
Academic Article
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Times cited: 27 -
PRMT5-mediated regulation of developmental myelination.
Nature communications.
2018
Academic Article
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Times cited: 69 -
Discovery of a drug candidate for GLIS3-associated diabetes.
Nature communications.
2018
Academic Article
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Times cited: 47 -
Male germ cells support long-term propagation of Zika virus.
Nature communications.
2018
Academic Article
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Times cited: 62 -
Derivation and characterization of a UCP1 reporter human ES cell line.
Stem cell research.
2018
Academic Article
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Times cited: 5 -
A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages.
Cell stem cell.
2017
Academic Article
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Times cited: 145 -
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.
Nature communications.
2017
Academic Article
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Times cited: 65 -
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis.
Cell reports.
2017
Academic Article
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Times cited: 78 -
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Cell stem cell.
2017
Academic Article
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Times cited: 198 -
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Nature medicine.
2017
Academic Article
GET IT
Times cited: 290 - Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells. Molecular biotechnology. 2017 Academic Article GET IT
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Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.
Cell reports.
2017
Academic Article
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Times cited: 18 -
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.
Cell stem cell.
2017
Academic Article
GET IT
Times cited: 126 -
Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling.
Current protocols in stem cell biology.
2017
Academic Article
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Times cited: 3 -
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells.
Scientific reports.
2017
Academic Article
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Times cited: 42 -
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.
Cell stem cell.
2016
Academic Article
GET IT
Times cited: 94 - A recellularized human colon model identifies cancer driver genes. Nature biotechnology. 2016 Academic Article GET IT
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Dynamic self-organization of microwell-aggregated cellular mixtures.
Soft matter.
2016
Academic Article
GET IT
Times cited: 17 -
Multifunctional in vivo imaging of pancreatic islets during diabetes development.
Journal of cell science.
2016
Academic Article
GET IT
Times cited: 22 -
Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation.
Cell reports.
2016
Academic Article
GET IT
Times cited: 22 -
Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.
Stem cells translational medicine.
2016
Academic Article
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Times cited: 42 -
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.
Nature.
2016
Academic Article
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Times cited: 240 -
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling.
Stem cell reports.
2015
Academic Article
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Times cited: 30 -
Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling.
Stem cell reports.
2015
Academic Article
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Times cited: 37 -
Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes.
Regenerative medicine.
2012
Information Resource
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Times cited: 6 -
Cardiac glycosides are potent inhibitors of interferon-β gene expression.
Nature chemical biology.
2010
Academic Article
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Times cited: 44 -
Generation of pluripotent stem cells from patients with type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
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Times cited: 475 -
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Cell stem cell.
2009
Academic Article
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Times cited: 368 -
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Nature chemical biology.
2009
Academic Article
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Times cited: 397 -
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.
Nature biotechnology.
2008
Academic Article
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Times cited: 1069 -
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.
Cell stem cell.
2007
Academic Article
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Times cited: 257 -
Reversine increases the plasticity of lineage-committed mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America.
2007
Academic Article
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Times cited: 86 -
Genetic incorporation of unnatural amino acids into proteins in mammalian cells.
Nature methods.
2007
Academic Article
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Times cited: 276 -
Self-renewal of embryonic stem cells by a small molecule.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 273 -
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 392 -
Exploring stem cell biology with small molecules.
Molecular bioSystems.
2005
Information Resource
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Times cited: 37 -
Dedifferentiation of lineage-committed cells by a small molecule.
Journal of the American Chemical Society.
2004
Academic Article
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Times cited: 258 - Orientation of the peptide formation of N-phosphoryl amino acids in solution. Chinese Science Bulletin. 2002 Article GET IT
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Negative-ion electrospray ionization tandem mass spectrometry of N-phosphoryl amino acids and dipeptides.
Rapid communications in mass spectrometry : RCM.
2002
Academic Article
GET IT
Times cited: 13 - The Fmoc-Strategy Solid-Phase Synthesis of O-Phosphopeptide. Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities. 2001 Article
- The study of phosphoramidite as O-phosphitylation agent and its reactivity. Phosphorus, Sulfur and Silicon and Related Elements. 2000 Article