Pahlajani, Silky

Publications

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selected publications

Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics. Scientific reports. 2026 Academic Article GET IT
Worse visibility of deep medullary veins is associated with larger lateral ventricles but not with cortical thickness. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2025 Academic Article GET IT
White matter microstructural and macrostructural profiles during midlife reveal sex differences between men and women at different menopausal stages. Scientific reports. 2025 Academic Article GET IT
Times cited: 1
PET-measured tau deposition in emotion-related brain regions is differentially associated with depressive symptoms in individuals with versus without Alzheimer's disease pathology. Behavioural brain research. 2025 Academic Article GET IT
Concordance between Centiloid Quantification and Visual Interpretation of Amyloid PET Scans across the Alzheimer Disease Continuum. AJNR. American journal of neuroradiology. 2025 Academic Article GET IT
Times cited: 7
Quantitative and simplified [18F] fluoroestradiol positron emission tomography (PET) measures of brain estrogen receptor expression. European journal of nuclear medicine and molecular imaging. 2025 Academic Article GET IT
Times cited: 1
Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?. AJNR. American journal of neuroradiology. 2025 Article GET IT
White matter micro- and macrostructural properties in midlife individuals at risk for Alzheimer's disease: Associations with sex and menopausal status. bioRxiv : the preprint server for biology. 2025 Article GET IT
Neurophysiological correlates of subjective cognitive decline in perimenopausal and postmenopausal midlife women at risk for Alzheimer's disease. Menopause (New York, N.Y.). 2025 Academic Article GET IT
Times cited: 3
Divergent neurodegeneration associations with choroid plexus volume and degree of calcification in cognitively normal APOE ε4 carriers and non-carriers. Scientific reports. 2025 Academic Article GET IT
Times cited: 4
Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer's disease. PloS one. 2025 Academic Article GET IT
Times cited: 7
Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Information Resource GET IT
Times cited: 29
Utilizing structural MRI and unsupervised clustering to differentiate schizophrenia and Alzheimer's disease in late-onset psychosis. Behavioural brain research. 2024 Academic Article GET IT
Times cited: 1
In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology. Scientific reports. 2024 Academic Article GET IT
Times cited: 51
Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease. Alzheimer disease and associated disorders. 2024 Academic Article GET IT
Times cited: 6
[1-¹¹C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects. Fluids and barriers of the CNS. 2024 Academic Article GET IT
Times cited: 7
Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer's risk. Scientific reports. 2024 Academic Article GET IT
Times cited: 10
Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition. Frontiers in endocrinology. 2024 Information Resource GET IT
Times cited: 49
Elevated gonadotropin levels are associated with increased biomarker risk of Alzheimer's disease in midlife women. Frontiers in dementia. 2023 Academic Article GET IT
Times cited: 16
Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer's disease and dementia. Frontiers in aging neuroscience. 2023 Information Resource GET IT
Times cited: 78
Systematic review of ³¹P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer's disease. Frontiers in aging neuroscience. 2023 Information Resource GET IT
Times cited: 21
In vivo Brain Estrogen Receptor Expression By Neuroendocrine Aging And Relationships With Gray Matter Volume, Bio-Energetics, and Clinical Symptomatology. Research square. 2023 Article GET IT
Times cited: 25
Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer's disease: A 31Phosphorus MR spectroscopy study. PloS one. 2023 Academic Article GET IT
Times cited: 9
Sex and menopause impact ³¹P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with ¹¹C-PiB PET amyloid-beta load. Scientific reports. 2022 Academic Article GET IT
Times cited: 17
Tau PET following acute TBI: Off-target binding to blood products, tauopathy, or both?. Frontiers in neuroimaging. 2022 Academic Article GET IT
Times cited: 5
Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer's disease. Frontiers in aging neuroscience. 2022 Information Resource GET IT
Times cited: 50
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. Neurobiology of disease. 2022 Information Resource GET IT
Times cited: 41
Decreased CSF clearance and increased brain amyloid in Alzheimer's disease. Fluids and barriers of the CNS. 2022 Academic Article GET IT
Times cited: 78
Endogenous and Exogenous Estrogen Exposures: How Women's Reproductive Health Can Drive Brain Aging and Inform Alzheimer's Prevention. Frontiers in aging neuroscience. 2022 Information Resource GET IT
Times cited: 93
Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife. Neurology. 2021 Academic Article GET IT
Times cited: 62
Heuristic scoring method utilizing FDG-PET statistical parametric mapping in the evaluation of suspected Alzheimer disease and frontotemporal lobar degeneration. American journal of nuclear medicine and molecular imaging. 2021 Academic Article GET IT
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition. Scientific reports. 2021 Academic Article GET IT
Times cited: 211
Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study. Neurology. 2020 Academic Article GET IT
Times cited: 141
Neurovascular Unit Dysfunction and Blood-Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence. Frontiers in psychiatry. 2017 Information Resource GET IT
Times cited: 192
Delayed Diagnosis of Glioblastoma Multiforme Presenting With Atypical Psychiatric Symptoms. The primary care companion for CNS disorders. 2016 Article GET IT
Times cited: 3
Liraglutide subcutaneous injection for weight loss: where does it fit?. International journal of clinical practice. 2015 Editorial Article GET IT
Times cited: 3

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Research

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Funding awarded

Tau progression index (TPI): An individualized predictor of Alzheimer''s Disease trajectory based on subject-specific connectomes awarded by National Institute on Aging Co-Investigator 2024 - 2029
Brain Estrogen Imaging and Neuroendocrine Risk Identification: The Gateway to Alzheimer''s Prevention in Women awarded by Wellcome Leap, Inc. Co-Investigator 2025 - 2028
Quantitative MRI-based cerebral oxygen metabolism in Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2023 - 2028
Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer''s disease biomarkers in hypertension awarded by National Heart, Lung, & Blood Institute Co-Investigator 2022 - 2027
PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial awarded by National Institute on Aging Co-Investigator 2022 - 2027
Understanding the dynamic interactions between tau pathology and microgliamediated inflammation in Alzheimer''s Disease awarded by National Institute on Minority Health & Health Disparities Co-Investigator 2024 - 2026
Perimenopause in Brain Aging and Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2021 - 2026

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Background

education and training

B.S., Houston Baptist University 2205
M.D., St. George's University School of Medicine (Grenada) 2011

Contact

full name

Silky Pahlajani

primary email

sip9018@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Silky Pahlajani Assistant Professor of Neuropsychiatry Research in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage