selected publications
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Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer.
Cancer discovery.
2024
Academic Article
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Times cited: 11 - Transcriptomic analysis reveals distinct effects of cigarette smoke on murine airspace and bone-marrow derived macrophages. Respiratory research. 2024 Letter GET IT
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Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation.
Nature communications.
2024
Academic Article
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Times cited: 10 - Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2024 Letter GET IT
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ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly.
ERJ open research.
2024
Academic Article
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Times cited: 3 -
Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD.
JCI insight.
2023
Academic Article
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Times cited: 12 -
LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages.
American journal of respiratory cell and molecular biology.
2023
Academic Article
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Times cited: 6 -
ERS International Congress 2022: highlights from the Basic and Translational Science Assembly.
ERJ open research.
2023
Academic Article
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Times cited: 3 - "KEAP"ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine. 2023 Editorial Article GET IT
- OLA1 Phosphorylation: A Distress Signal from Damaged Endothelial Mitochondria?. American journal of respiratory cell and molecular biology. 2023 Editorial Article GET IT
- Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology. 2023 Letter GET IT
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Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD.
Clinical science (London, England : 1979).
2023
Academic Article
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Times cited: 6 -
Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress.
Frontiers in immunology.
2022
Academic Article
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Times cited: 11 - Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy. Cell reports. 2022 Academic Article GET IT
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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages.
The Journal of biological chemistry.
2021
Academic Article
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Times cited: 36 -
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis.
Nature communications.
2021
Academic Article
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Times cited: 182 -
Reversal of emphysema by restoration of pulmonary endothelial cells.
The Journal of experimental medicine.
2021
Academic Article
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Times cited: 55 -
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2.
eLife.
2021
Academic Article
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Times cited: 23 -
Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.
Respiratory research.
2021
Review
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Times cited: 43 -
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.
Respiratory research.
2021
Academic Article
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Times cited: 21 -
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
2020
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Times cited: 8 -
Mitochondrial dysfunction in lung ageing and disease.
European respiratory review : an official journal of the European Respiratory Society.
2020
Review
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Times cited: 80 -
Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model.
Journal of immunology (Baltimore, Md. : 1950).
2020
Academic Article
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Times cited: 17 -
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.
Scientific reports.
2020
Academic Article
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Times cited: 20 -
To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model.
American journal of respiratory cell and molecular biology.
2020
Editorial Article
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Times cited: 3 -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.
Science (New York, N.Y.).
2020
Academic Article
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Times cited: 104 -
Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine.
2020
Letter
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Times cited: 51 -
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.
JCI insight.
2020
Academic Article
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Times cited: 33 -
Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.
American journal of physiology. Lung cellular and molecular physiology.
2019
Review
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Times cited: 91 -
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.
Nature communications.
2019
Academic Article
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Times cited: 137 -
ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients.
Scientific reports.
2019
Academic Article
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Times cited: 21 -
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.
JCI insight.
2019
Academic Article
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Times cited: 23 -
Mitochondrial Iron in Human Health and Disease.
Annual review of physiology.
2018
Review
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Times cited: 160 -
Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.
JCI insight.
2018
Academic Article
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Times cited: 19 -
Smoking-induced iron dysregulation in the lung.
Free radical biology & medicine.
2018
Review
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Times cited: 41 -
Circulating RIPK3 levels are associated with mortality and organ failure during critical illness.
JCI insight.
2018
Academic Article
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Times cited: 34 -
Autophagy and inflammation in chronic respiratory disease.
Autophagy.
2018
Information Resource
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Times cited: 430 -
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics.
2018
Academic Article
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Times cited: 78 -
Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis.
American journal of respiratory and critical care medicine.
2017
Editorial Article
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Times cited: 7 -
The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine.
2017
Academic Article
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Times cited: 87 -
Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.
Scientific reports.
2017
Academic Article
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Times cited: 89 -
Autophagy: Friend or Foe in Lung Disease?.
Annals of the American Thoracic Society.
2016
Review
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Times cited: 83 -
Mitochondria in lung disease.
The Journal of clinical investigation.
2016
Review
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Times cited: 232 -
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Nature medicine.
2016
Academic Article
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Times cited: 204 -
Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.
Journal of medicinal chemistry.
2015
Academic Article
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Times cited: 83 -
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
The Journal of clinical investigation.
2014
Academic Article
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Times cited: 510 -
"Ciliophagy": The consumption of cilia components by autophagy.
Autophagy.
2014
Review
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Times cited: 78 -
Synthesis and antiproliferative action of a novel series of maprotiline analogues.
European journal of medicinal chemistry.
2013
Academic Article
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Times cited: 16 -
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
The Journal of clinical investigation.
2013
Academic Article
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Times cited: 261 -
Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease.
Antioxidants & redox signaling.
2013
Information Resource
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Times cited: 103 -
Mitochondria: sensors and mediators of innate immune receptor signaling.
Current opinion in microbiology.
2013
Review
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Times cited: 57 -
Autophagy: a critical regulator of cellular metabolism and homeostasis.
Molecules and cells.
2013
Review
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Times cited: 297 -
The emerging importance of autophagy in pulmonary diseases.
Chest.
2012
Review
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Times cited: 111 -
Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease.
International journal of hypertension.
2012
Academic Article
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Times cited: 65 -
Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages.
Dalton transactions (Cambridge, England : 2003).
2012
Academic Article
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Times cited: 50 -
Mitochondria: commanders of innate immunity and disease?.
Current opinion in immunology.
2011
Review
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Times cited: 80 -
Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents.
Journal of the American Chemical Society.
2011
Academic Article
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Times cited: 152 -
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.
Bioorganic & medicinal chemistry.
2010
Academic Article
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Times cited: 24 -
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
Oncology reports.
2010
Academic Article
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Times cited: 10 -
Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.
Chemical communications (Cambridge, England).
2010
Academic Article
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Times cited: 37 -
The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma.
International journal of cancer.
2010
Academic Article
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Times cited: 87 -
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.
Bioorganic & medicinal chemistry.
2010
Academic Article
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Times cited: 9 -
The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters.
Leukemia & lymphoma.
2010
Academic Article
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Times cited: 47 -
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
European journal of medicinal chemistry.
2009
Academic Article
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Times cited: 22 -
Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
Molecular pharmacology.
2006
Academic Article
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Times cited: 60