selected publications Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. eNeuro. 2024 Academic Article GET IT Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. 2024 GET IT Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. bioRxiv. https://www.biorxiv.org/content/10.1101/2024.05.28.596050v1. 2024 Academic Article Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s disease. https://doi.org/10.1101/2023.02.15.528710. BioRxiv. 2023 Academic Article Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nature communications. 2021 Academic Article GET IT Times cited: 23 Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke. Circulation research. 2020 Academic Article GET IT Times cited: 80 The isolation and molecular characterization of cerebral microvessels. Nature protocols. 2019 Academic Article GET IT Times cited: 9 Evaluation of S1PR1, pSTAT3, S1PR2, FOXP1 Expression in Aggressive, Mature B Cell Lymphomas. Journal of hematopathology. 2019 Academic Article GET IT Times cited: 5 An engineered S1P chaperone attenuates hypertension and ischemic injury. Science signaling. 2017 Academic Article GET IT Times cited: 84 Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT Times cited: 154 Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke. Nature communications. 2015 Academic Article GET IT Times cited: 123 Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Academic Article GET IT Times cited: 144 Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Laboratory investigation; a journal of technical methods and pathology. 2013 Academic Article GET IT Times cited: 38 S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. The Journal of urology. 2009 Academic Article GET IT Times cited: 24 S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer letters. 2009 Academic Article GET IT Times cited: 52 Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Molecular cancer research : MCR. 2008 Academic Article GET IT Times cited: 59 Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. The Journal of biological chemistry. 2008 Academic Article GET IT Times cited: 44 Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. The Journal of clinical investigation. 2007 Academic Article GET IT Times cited: 195 Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arteriosclerosis, thrombosis, and vascular biology. 2007 Academic Article GET IT Times cited: 220 Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer research. 2006 Academic Article GET IT Times cited: 237 GR 63799X, an EP3 receptor agonist, induced S phase arrest and 3T6 fibroblast growth inhibition. European journal of pharmacology. 2005 Academic Article GET IT Times cited: 9 PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT Times cited: 137 Structural and functional characteristics of S1P receptors. Journal of cellular biochemistry. 2004 Information Resource GET IT Times cited: 384 Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. The Journal of biological chemistry. 2003 Academic Article GET IT Times cited: 341 Calcium-independent phospholipase A2 through arachidonic acid mobilization is involved in Caco-2 cell growth. Journal of cellular physiology. 2002 Academic Article GET IT Times cited: 37 Role of EP(1) and EP(4) PGE(2) subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation. American journal of physiology. Cell physiology. 2002 Academic Article GET IT Times cited: 36 Role of phospholipases A(2) in growth-dependent changes in prostaglandin release from 3T6 fibroblasts. Journal of cellular physiology. 2001 Academic Article GET IT Times cited: 10 Olive oil decreases both oxidative stress and the production of arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages. The Journal of nutrition. 2001 Academic Article GET IT Times cited: 63 The effect of high molecular phospholipase A2 inhibitors on 3T6 fibroblast proliferation. Biochemical pharmacology. 2001 Academic Article GET IT Times cited: 24 Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. The Journal of biological chemistry. 2000 Academic Article GET IT Times cited: 69 Regulation of prostaglandin E2 production by the superoxide radical and nitric oxide in mouse peritoneal macrophages. Free radical research. 2000 Academic Article GET IT Times cited: 42 Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin. Biochemical pharmacology. 1999 Academic Article GET IT Times cited: 36 Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin. Prostaglandins & other lipid mediators. 1999 Academic Article GET IT Times cited: 27 Ketoprofen S(+) enantiomer inhibits prostaglandin production and cell growth in 3T6 fibroblast cultures. European journal of pharmacology. 1999 Academic Article GET IT Times cited: 18 Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts. Biochemical pharmacology. 1998 Academic Article GET IT Times cited: 4 Role of prostaglandin H synthase-2-mediated conversion of arachidonic acid in controlling 3T6 fibroblast growth. The American journal of physiology. 1997 Academic Article GET IT Times cited: 39
Funding awarded Endothelial Sphingolipid Signaling in Post-Sepsis Cognitive Impairment. awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2025 Endothelial Sphingolipid Signaling in Neurovascular Ischemic Injury awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2025 Stalled Capillary Flow: a Novel Mechanism for Hypoperfusion in Alzheimer's Disease Co-Principal Investigator
education and training Pharm.B., University of Barcelona (Spain) 96 Ph.D., University of Barcelona (Spain) 2001 M.S., University of Barcelona (Spain) 1997