selected publications
- Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland. Communications biology. 2023 Academic Article GET IT
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International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.
Pharmacological reviews.
2023
Review
GET IT
Times cited: 9 - Regulation of thyroid hormone levels by hypothalamic TRH (thyrotropin-releasing hormone) neurons. Thyroid : official journal of the American Thyroid Association. 2023 Academic Article GET IT
- The role of WD40 repeat-containing proteins in endocrine (dys)function. Journal of molecular endocrinology. 2023 Review GET IT
- Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell reports. 2022 Academic Article GET IT
- Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. PloS one. 2022 Academic Article GET IT
- Impact of the KL2/Catalyst Medical Research Investigator Training (CMeRIT) Program on the careers of early-stage clinical and translational investigators. Journal of clinical and translational science. 2022 Academic Article GET IT
- Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. Science signaling. 2021 Academic Article GET IT
- Early Life Stress Affects the HPT Axis Response in a Sexually Dimorphic Manner. Endocrinology. 2021 Article GET IT
- Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Molecular metabolism. 2021 Academic Article GET IT
- Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Frontiers in endocrinology. 2021 Information Resource GET IT
- A joint industry-sponsored data monitoring committee model for observational, retrospective drug safety studies in the real-world setting. Pharmacoepidemiology and drug safety. 2020 Academic Article GET IT
- SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 Academic Article GET IT
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Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City.
The Journal of clinical investigation.
2020
Academic Article
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Times cited: 8 -
Thyroid Hormone Signaling and the Liver.
Hepatology (Baltimore, Md.).
2020
Information Resource
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Times cited: 11 -
Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone.
PLoS genetics.
2020
Academic Article
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Times cited: 23 -
Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.
PloS one.
2019
Academic Article
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Times cited: 12 -
Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.
Thyroid : official journal of the American Thyroid Association.
2019
Academic Article
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Times cited: 55 -
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Nature communications.
2019
Academic Article
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Times cited: 43 -
Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha.
Thyroid : official journal of the American Thyroid Association.
2019
Academic Article
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Times cited: 8 -
Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
Science signaling.
2018
Academic Article
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Times cited: 32 -
T3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells.
Diabetes.
2018
Academic Article
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Times cited: 15 -
Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.
The Journal of biological chemistry.
2017
Academic Article
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Times cited: 13 -
A Field Experiment on Search Costs and the Formation of Scientific Collaborations.
The review of economics and statistics.
2017
Academic Article
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Times cited: 51 -
Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification.
Development (Cambridge, England).
2017
Academic Article
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Times cited: 66 -
NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 21 -
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Cell metabolism.
2017
Academic Article
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Times cited: 66 -
Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.
The Journal of clinical investigation.
2017
Academic Article
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Times cited: 162 -
New insights into thyroid hormone action.
Pharmacology & therapeutics.
2017
Information Resource
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Times cited: 185 -
Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1.
Stem cell reports.
2017
Academic Article
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Times cited: 37 -
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
Autophagy.
2016
Academic Article
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Times cited: 36 -
Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells.
Endocrinology.
2016
Academic Article
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Times cited: 33 -
HDAC3 Is a Master Regulator of mTEC Development.
Cell reports.
2016
Academic Article
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Times cited: 26 -
Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.
Cell stem cell.
2015
Academic Article
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Times cited: 155 -
Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
The Journal of biological chemistry.
2015
Academic Article
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Times cited: 39 -
ISL1 Is Necessary for Maximal Thyrotrope Response to Hypothyroidism.
Molecular endocrinology (Baltimore, Md.).
2015
Academic Article
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Times cited: 15 -
Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.
Endocrinology.
2015
Academic Article
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Times cited: 30 -
Endocrine disorders in Fanconi anemia: recommendations for screening and treatment.
The Journal of clinical endocrinology and metabolism.
2015
Information Resource
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Times cited: 72 -
NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.
Molecular and cellular biology.
2014
Academic Article
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Times cited: 43 -
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.
The Journal of clinical investigation.
2014
Academic Article
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Times cited: 30 -
Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.
Endocrinology.
2014
Academic Article
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Times cited: 35 -
Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.
Molecular and cellular biology.
2014
Academic Article
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Times cited: 47 -
Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.
Hormones and behavior.
2013
Editorial Article
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Times cited: 3 -
Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 93 -
Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.
Frontiers in neuroendocrinology.
2013
Editorial Article
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Times cited: 1 - Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al. Andrology. 2013 Article GET IT
-
Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 37 -
Family members CREB and CREM control thyrotropin-releasing hormone (TRH) expression in the hypothalamus.
Molecular and cellular endocrinology.
2012
Academic Article
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Times cited: 11 -
The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
Endocrinology.
2012
Academic Article
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Times cited: 32 -
The in vivo role of nuclear receptor corepressors in thyroid hormone action.
Biochimica et biophysica acta.
2012
Information Resource
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Times cited: 70 -
Metabolic health and nuclear-receptor sensitivity.
The New England journal of medicine.
2012
Academic Article
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Times cited: 9 -
Reducing systemic hypermetabolism by inducing hypothyroidism does not prolong survival in the SOD1-G93A mouse.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
2012
Academic Article
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Times cited: 6 -
NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways.
Cell metabolism.
2011
Academic Article
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Times cited: 87 -
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
Proceedings of the National Academy of Sciences of the United States of America.
2011
Academic Article
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Times cited: 42 -
PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism.
Molecular endocrinology (Baltimore, Md.).
2011
Academic Article
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Times cited: 26 -
The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.
Molecular endocrinology (Baltimore, Md.).
2011
Academic Article
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Times cited: 76 -
Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 24 -
Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.
Molecular endocrinology (Baltimore, Md.).
2010
Academic Article
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Times cited: 77 -
Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level.
American journal of physiology. Endocrinology and metabolism.
2010
Academic Article
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Times cited: 67 -
Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 33 -
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 121 -
The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo.
Endocrinology.
2009
Academic Article
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Times cited: 47 -
Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study.
BMJ (Clinical research ed.).
2009
Academic Article
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Times cited: 76 -
The thyroid hormone receptor recruits NCoR via widely spaced receptor-interacting domains.
Molecular and cellular endocrinology.
2009
Academic Article
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Times cited: 11 -
STAT3 targets the regulatory regions of gluconeogenic genes in vivo.
Molecular endocrinology (Baltimore, Md.).
2009
Academic Article
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Times cited: 88 -
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 135 -
Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.
Molecular cancer therapeutics.
2008
Academic Article
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Times cited: 51 -
The thyroid and metabolism: the action continues.
Cell metabolism.
2008
Conference Paper
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Times cited: 16 -
The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor.
Thyroid : official journal of the American Thyroid Association.
2008
Information Resource
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Times cited: 90 -
Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors.
Cancer research.
2007
Academic Article
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Times cited: 74 -
Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells.
The Journal of biological chemistry.
2006
Academic Article
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Times cited: 149 -
Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor.
The Journal of comparative neurology.
2005
Academic Article
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Times cited: 90 -
The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 114 -
Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells.
Molecular endocrinology (Baltimore, Md.).
2004
Academic Article
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Times cited: 63 -
Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 144 -
The metabolic and cardiovascular effects of hyperthyroidism are largely independent of beta-adrenergic stimulation.
Endocrinology.
2004
Academic Article
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Times cited: 41 -
Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo.
Endocrinology.
2004
Academic Article
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Times cited: 96 -
Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma.
Clinical endocrinology.
2003
Academic Article
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Times cited: 55 -
Leucine at codon 428 in the ninth heptad of thyroid hormone receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of dimer formations.
Thyroid : official journal of the American Thyroid Association.
2003
Academic Article
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Times cited: 4 -
Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation.
Molecular and cellular neurosciences.
2003
Academic Article
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Times cited: 28 -
Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin.
Endocrinology.
2003
Academic Article
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Times cited: 245 -
Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003
Academic Article
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Times cited: 251 -
Cellular context of coregulator and adaptor proteins regulates human adenovirus 5 early region 1A-dependent gene activation by the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.).
2003
Academic Article
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Times cited: 17 -
Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.).
2003
Academic Article
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Times cited: 61 -
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
The Journal of biological chemistry.
2002
Academic Article
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Times cited: 94 -
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons.
The Journal of clinical investigation.
2002
Academic Article
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Times cited: 472 -
Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor.
Molecular endocrinology (Baltimore, Md.).
2002
Academic Article
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Times cited: 100 -
Leptin and melanocortin signaling in the hypothalamus.
Vitamins and hormones.
2002
Information Resource
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Times cited: 25 -
The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains.
Molecular endocrinology (Baltimore, Md.).
2001
Academic Article
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Times cited: 101 -
Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells.
Molecular and cellular endocrinology.
2001
Academic Article
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Times cited: 16 -
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.
The Journal of clinical investigation.
2001
Academic Article
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Times cited: 287 -
Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 168 -
cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 47 -
The nuclear corepressors recognize distinct nuclear receptor complexes.
Molecular endocrinology (Baltimore, Md.).
2000
Academic Article
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Times cited: 88 -
Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring.
The Journal of clinical investigation.
2000
Article
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Times cited: 196 -
Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 65 -
p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
Molecular endocrinology (Baltimore, Md.).
1999
Academic Article
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Times cited: 27 -
Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.
The Journal of biological chemistry.
1998
Academic Article
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Times cited: 105 -
Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements.
Molecular endocrinology (Baltimore, Md.).
1998
Academic Article
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Times cited: 63 -
Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 59 -
A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 95 -
Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 260 -
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 229 -
Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.).
1997
Academic Article
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Times cited: 48 -
Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain.
The Journal of biological chemistry.
1996
Academic Article
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Times cited: 85 -
A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene.
The Journal of clinical investigation.
1996
Academic Article
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Times cited: 111 -
Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini.
The Journal of biological chemistry.
1995
Academic Article
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Times cited: 71 -
The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements.
Molecular endocrinology (Baltimore, Md.).
1995
Academic Article
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Times cited: 161 -
A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition.
The Journal of biological chemistry.
1994
Academic Article
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Times cited: 49 -
c-Jun represses transcription of the human chorionic gonadotropin alpha and beta genes through distinct types of CREs.
The Journal of biological chemistry.
1994
Academic Article
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Times cited: 76 -
Multiple promoter elements in the human chorionic gonadotropin beta subunit genes distinguish their expression from the luteinizing hormone beta gene.
Molecular and cellular endocrinology.
1994
Academic Article
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Times cited: 36 -
Dynamic regulation of gonadotropin-releasing hormone receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle.
Endocrinology.
1993
Academic Article
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Times cited: 98 -
The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence.
The Journal of biological chemistry.
1984
Academic Article
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Times cited: 78