Bracken, W. Clay

Publications

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selected publications

Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM. Journal of the American Chemical Society. 2023 Academic Article GET IT
Simultaneous estimation of the cellular water exchange rate, intracellular volume fraction, and longitudinal relaxation rate in cancer cells. NMR in biomedicine. 2023 Academic Article GET IT
Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. The Journal of biological chemistry. 2021 Academic Article GET IT
Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver. Hepatology (Baltimore, Md.). 2020 Academic Article GET IT
Times cited: 4
Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination. Metallomics : integrated biometal science. 2020 Academic Article GET IT
Times cited: 1
Use of paramagnetic ¹⁹F NMR to monitor domain movement in a glutamate transporter homolog. Nature chemical biology. 2020 Academic Article GET IT
Times cited: 25
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Academic Article GET IT
Times cited: 39
NMR backbone resonance assignments of the prodomain variants of BDNF in the urea denatured state. Biomolecular NMR assignments. 2017 Academic Article GET IT
Times cited: 3
Structural Model of the Extracellular Assembly of the TCR-CD3 Complex. Cell reports. 2016 Academic Article GET IT
Times cited: 39
Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Academic Article GET IT
Times cited: 24
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Molecular cell. 2013 Academic Article GET IT
Times cited: 136
Assessment of the abuse liability of ABT-288, a novel histamine H₃ receptor antagonist. Psychopharmacology. 2013 Academic Article GET IT
Times cited: 8
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature communications. 2013 Academic Article GET IT
Times cited: 172
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 92
Assembling ligands in situ using bioorthogonal boronate ester synthesis. Chemistry & biology. 2010 Academic Article GET IT
Times cited: 31
Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Academic Article GET IT
Times cited: 52
The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Academic Article GET IT
Times cited: 40
Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix. Biochemistry. 2008 Academic Article GET IT
Times cited: 26
Spin relaxation enhancement confirms dominance of extended conformations in short alanine peptides. Angewandte Chemie (International ed. in English). 2007 Academic Article GET IT
Times cited: 27
Polyproline II propensities from GGXGG peptides reveal an anticorrelation with beta-sheet scales. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 142
NMR investigation of main-chain dynamics of the H80E mutant of bovine neurophysin-I: demonstration of dimerization-induced changes at the hormone-binding site. Biochemistry. 2005 Academic Article GET IT
Times cited: 3
pH dependence of amide chemical shifts in natively disordered polypeptides detects medium-range interactions with ionizable residues. Biophysical journal. 2005 Academic Article GET IT
Times cited: 16
Helix formation and the unfolded state of a 52-residue helical protein. Protein science : a publication of the Protein Society. 2004 Academic Article GET IT
Times cited: 19
An effective method for the discrimination of motional anisotropy and chemical exchange. Journal of the American Chemical Society. 2002 Academic Article GET IT
Times cited: 116
A method for efficient isotopic labeling of recombinant proteins. Journal of biomolecular NMR. 2001 Academic Article GET IT
Times cited: 578
The DNA-binding domain in the Bacillus subtilis transition-state regulator AbrB employs significant motion for promiscuous DNA recognition. Journal of molecular biology. 2001 Academic Article GET IT
Times cited: 21
NMR spin relaxation methods for characterization of disorder and folding in proteins. Journal of molecular graphics & modelling. 2001 Academic Article GET IT
Times cited: 39
Buried polar interactions and conformational stability in the simian immunodeficiency virus (SIV) gp41 core. Biochemistry. 2000 Academic Article GET IT
Times cited: 28
Characterization of millisecond time-scale dynamics in the molten globule state of alpha-lactalbumin by NMR. Journal of molecular biology. 1999 Academic Article GET IT
Times cited: 35
Temperature dependence of intramolecular dynamics of the basic leucine zipper of GCN4: implications for the entropy of association with DNA. Journal of molecular biology. 1999 Academic Article GET IT
Times cited: 195
CO_H(N)CACB experiments for assigning backbone resonances in 13C/15N-labeled proteins. Journal of biomolecular NMR. 1998 Academic Article GET IT
Times cited: 4
(H)N(COCA)NH and HN(COCA)NH experiments for 1H-15N backbone assignments in 13C/15N-labeled proteins. Journal of biomolecular NMR. 1997 Academic Article GET IT
Times cited: 39
Alpha-helix to random coil transitions of two-chain coiled coils: experiments on the thermal denaturation of beta beta tropomyosin cross-linked selectively at C36. Biopolymers. 1990 Academic Article GET IT
Times cited: 15
Alpha-helix-to-random-coil transitions of two-chain coiled coils: experiments on the thermal denaturation of beta beta tropomyosin cross-linked selectively at C-190. Biopolymers. 1988 Academic Article GET IT
Times cited: 15

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Research

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Funding awarded

Modernization and Expansion of the Citigroup Biomedical Imaging Center at Weill Cornell Medical College awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2026

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Background

education and training

Ph.D., Rutgers-The State University of New Jersey 1995
B.A., Hendrix College 1985

Contact

full name

W. Clay Bracken

primary email

wcb2001@med.cornell.edu

VIVO Weill Cornell Medical College

W. Clay Bracken Associate Professor of Research in Biochemistry

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email