Chen, Wenhao

selected publications

PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 120
T cell exhaustion is associated with antigen abundance and promotes transplant acceptance. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 35
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 15
T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2019 Academic Article GET IT
Times cited: 11
Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Academic Article GET IT
Times cited: 21
OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms. Cell reports. 2018 Academic Article GET IT
Times cited: 97
Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts. Transplant immunology. 2018 Academic Article GET IT
Times cited: 12
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction. Immunity. 2017 Academic Article GET IT
Times cited: 81
Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2017 Academic Article GET IT
Times cited: 68
Anti-TCRβ mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice. Endocrinology. 2017 Academic Article GET IT
Times cited: 6
Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference. Cell and tissue research. 2016 Academic Article GET IT
Times cited: 14
Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2016 Academic Article GET IT
Times cited: 39
The Evolving Roles of Memory Immune Cells in Transplantation. Transplantation. 2015 Information Resource GET IT
Times cited: 17
Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Academic Article GET IT
Times cited: 12
PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy. Diabetologia. 2015 Academic Article GET IT
Times cited: 3
PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2014 Academic Article GET IT
Times cited: 20
TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation. Molecular immunology. 2014 Academic Article GET IT
Times cited: 2
Molecular insights into the development of T cell-based immunotherapy for prostate cancer. Expert review of clinical immunology. 2014 Review GET IT
Times cited: 8
Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. Transplantation. 2014 Academic Article GET IT
Times cited: 4
MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. Journal of molecular and cellular cardiology. 2014 Academic Article GET IT
Times cited: 30
Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions. PloS one. 2014 Academic Article GET IT
Times cited: 12
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. PloS one. 2013 Academic Article GET IT
Times cited: 4
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 68
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 16
Digoxin attenuates acute cardiac allograft rejection by antagonizing RORγt activity. Transplantation. 2013 Academic Article GET IT
Times cited: 23
Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Translational research : the journal of laboratory and clinical medicine. 2013 Review GET IT
Times cited: 23
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012 Academic Article GET IT
Times cited: 19
CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 26
Treatment with interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection. Transplantation. 2011 Academic Article GET IT
Times cited: 25
IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation. Immunology letters. 2010 Academic Article GET IT
Times cited: 23
"Default" generation of neonatal regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 118
IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4+ T cells. Immunology letters. 2010 Academic Article GET IT
Times cited: 5
Expanding and converting regulatory T cells: a horizon for immunotherapy. Archivum immunologiae et therapiae experimentalis. 2009 Review GET IT
Times cited: 29
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 268
STAT3: an important regulator of multiple cytokine functions. Transplantation. 2008 Review GET IT
Times cited: 69
Functional quartet by CD4+ T cells: a concerto of multiple cytokines. Expert review of clinical immunology. 2008 Editorial Article GET IT
Times cited: 2
Antigen transmission by replicating antigen-bearing dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 18
Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 16
Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development. European journal of immunology. 2007 Academic Article GET IT
Times cited: 54
Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2007 Academic Article GET IT
Times cited: 3
Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 51
FcR gamma presence in TCR complex of double-negative T cells is critical for their regulatory function. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 19
In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in lymphoid tissue. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 88
CXCR5/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 29
Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 57
Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts. Circulation. 2005 Academic Article GET IT
Times cited: 58
Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 35
Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation. 2005 Academic Article GET IT
Times cited: 10
The role and mechanisms of double negative regulatory T cells in the suppression of immune responses. Cellular & molecular immunology. 2004 Review GET IT
Times cited: 53
Characterization of distinct conventional and plasmacytoid dendritic cell-committed precursors in murine bone marrow. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 94
Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice. Transplantation proceedings. 2003 Academic Article GET IT
Times cited: 38
Role of double-negative regulatory T cells in long-term cardiac xenograft survival. Journal of immunology (Baltimore, Md. : 1950). 2003 Academic Article GET IT
Times cited: 66
An oral formulation for intracellular adhesion molecules-1 antisense oligonucleotides. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 4
Development of an oral formulation for ICAM-1 antisense oligonucleotides. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 3
Methoxyethyl modification of phosphorothioate ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 6
Phosphorothioate/methoxyethyl-modified ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 12
Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats. Transplantation. 2000 Academic Article GET IT
Times cited: 21
Perfusion of kidneys with unformulated "naked" intercellular adhesion molecule-1 antisense oligodeoxynucleotides prevents ischemic/reperfusion injury. Transplantation. 1999 Academic Article GET IT
Times cited: 38
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature medicine. 1998 Academic Article GET IT
Times cited: 373
Protection against allograft rejection with intercellular adhesion molecule-1 antisense oligodeoxynucleotides. Transplantation. 1998 Academic Article GET IT
Times cited: 59

VIVO Weill Cornell Medical College

Wenhao Chen Assistant Professor of Immunology in Surgery

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