Luo, Wenjie

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Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
Correction: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. 2024 GET IT
APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2024 GET IT
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 Academic Article GET IT
Times cited: 3
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024 GET IT
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. 2023 GET IT
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. 2023 GET IT
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. Molecular neurodegeneration. 2023 Academic Article GET IT
Functional characterization of Alzheimer's disease genetic variants in microglia. Nature genetics. 2023 Academic Article GET IT
Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging. 2023 GET IT
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023 GET IT
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 32
Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. 2022 Editorial Article GET IT
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications. 2022 Academic Article GET IT
Times cited: 123
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 50
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022 Academic Article GET IT
Times cited: 121
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science translational medicine. 2021 Academic Article GET IT
Times cited: 58
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. The Journal of experimental medicine. 2021 Academic Article GET IT
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life science alliance. 2021 Academic Article GET IT
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. Nature communications. 2021 Academic Article GET IT
Times cited: 95
A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase. ACS chemical neuroscience. 2020 Academic Article GET IT
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. Journal of neuroinflammation. 2020 Academic Article GET IT
Times cited: 64
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nature communications. 2020 Academic Article GET IT
Times cited: 44
The complexity of tau in Alzheimer's disease. Neuroscience letters. 2019 Review GET IT
Times cited: 233
Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells. Nature biotechnology. 2018 Academic Article GET IT
Times cited: 74
A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes. Scientific reports. 2017 Academic Article GET IT
Times cited: 21
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017 Academic Article GET IT
Times cited: 788
ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury. Scientific reports. 2017 Academic Article GET IT
Times cited: 49
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 Academic Article GET IT
Times cited: 63
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 Academic Article GET IT
Times cited: 444
δ-COP modulates Aβ peptide formation via retrograde trafficking of APP. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 15
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Academic Article GET IT
Times cited: 131
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. 2015 Academic Article GET IT
Times cited: 169
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40. Molecular neurodegeneration. 2014 Academic Article GET IT
Times cited: 42
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention. Current Alzheimer research. 2014 Academic Article GET IT
Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Academic Article GET IT
Times cited: 19
Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators. Assay and drug development technologies. 2010 Academic Article GET IT
Times cited: 3
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature. 2010 Academic Article GET IT
Times cited: 286
A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron. 2009 Academic Article GET IT
Times cited: 36
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 238
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 102
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 41
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 205
An ER membrane protein, Sop4, facilitates ER export of the yeast plasma membrane [H+]ATPase, Pma1. Traffic (Copenhagen, Denmark). 2002 Academic Article GET IT
Times cited: 21
Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 76
An endosome-to-plasma membrane pathway involved in trafficking of a mutant plasma membrane ATPase in yeast. Molecular biology of the cell. 2000 Academic Article GET IT
Times cited: 65

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Research

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Funding awarded

Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2020 - 2025

Discovery of first-in-class small molecule TREM2 ligands as therapeutics for Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2024 - 2029
Elucidating the Cell-Type Specific Neuroprotective Mechanisms in the APOE3 Christchurch Mutation in Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2023 - 2026
Linking tau proteostasis with neuronal activity in FTD awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2018 - 2023

Modeling pathological Tau propagation in human brain cells in vivo awarded by BrightFocus Foundation Key Personnel 2024 - 2026

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Background

education and training

M.S., Peking University (China) 94
B.S., Peking University (China) 91
Ph.D., Albert Einstein College of Medicine of Yeshiva University 2001

Contact

full name

Wenjie Luo

primary email

wel2009@med.cornell.edu

VIVO Weill Cornell Medical College

Wenjie Luo Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email