Li, Xian

Publications

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selected publications

PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 108
EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. EMBO reports. 2020 Academic Article GET IT
Times cited: 33
T cell exhaustion is associated with antigen abundance and promotes transplant acceptance. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 31
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 13
T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2019 Academic Article GET IT
Times cited: 9
Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions. Journal of immunology (Baltimore, Md. : 1950). 2019 Academic Article GET IT
Times cited: 29
Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Academic Article GET IT
Times cited: 20
OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms. Cell reports. 2018 Academic Article GET IT
Times cited: 82
Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts. Transplant immunology. 2018 Academic Article GET IT
Times cited: 12
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus. Journal of immunology (Baltimore, Md. : 1950). 2018 Academic Article GET IT
Times cited: 59
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. The Journal of experimental medicine. 2018 Academic Article GET IT
Times cited: 54
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction. Immunity. 2017 Academic Article GET IT
Times cited: 76
Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2017 Academic Article GET IT
Times cited: 60
Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2017 Academic Article GET IT
Times cited: 11
TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nature communications. 2017 Academic Article GET IT
Times cited: 149
TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 47
Leukocyte immunoglobulin-like receptors in human diseases: an overview of their distribution, function, and potential application for immunotherapies. Journal of leukocyte biology. 2017 Information Resource GET IT
Times cited: 29
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. Nature immunology. 2016 Academic Article GET IT
Times cited: 126
Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference. Cell and tissue research. 2016 Academic Article GET IT
Times cited: 14
The Emerging Role of Nanotechnology in Cell and Organ Transplantation. Transplantation. 2016 Information Resource GET IT
Times cited: 35
The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways. Immunity. 2016 Academic Article GET IT
Times cited: 59
Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016 Academic Article GET IT
Times cited: 53
Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3. Experimental cell research. 2016 Academic Article GET IT
Times cited: 23
Efficacy and cost-effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high-risk liver transplant recipients. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2016 Academic Article GET IT
Times cited: 15
ROCK inhibition impedes macrophage polarity and functions. Cellular immunology. 2015 Academic Article GET IT
Times cited: 30
The Evolving Roles of Memory Immune Cells in Transplantation. Transplantation. 2015 Information Resource GET IT
Times cited: 17
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nature communications. 2015 Academic Article GET IT
Times cited: 89
Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Cell reports. 2015 Academic Article GET IT
Times cited: 85
Pericytes, microvasular dysfunction, and chronic rejection. Transplantation. 2015 Information Resource GET IT
Times cited: 22
Organ transplantation in China--not yet a new era--Authors' reply. Lancet (London, England). 2014 Article GET IT
Times cited: 1
A new era for organ transplantation in China. Lancet (London, England). 2014 Article GET IT
Times cited: 13
A naturally occurring CD8(+)CD122(+) T-cell subset as a memory-like Treg family. Cellular & molecular immunology. 2014 Information Resource GET IT
Times cited: 47
Immunological aspect on late allograft dysfunction. Journal of immunology research. 2014 Editorial Article GET IT
Memory T Cells Mediate Cardiac Allograft Vasculopathy and are Inactivated by Anti-OX40L Monoclonal Antibody. Cardiovascular drugs and therapy. 2014 Academic Article GET IT
Times cited: 19
CD86 is an activation receptor for NK cell cytotoxicity against tumor cells. PloS one. 2013 Academic Article GET IT
Times cited: 31
The newly found functions of MTOC in immunological response. Journal of leukocyte biology. 2013 Information Resource GET IT
Times cited: 17
Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways. Transplantation. 2013 Academic Article GET IT
Times cited: 14
Natural CD8+CD122+ T cells are more potent in suppression of allograft rejection than CD4+CD25+ regulatory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013 Academic Article GET IT
Times cited: 54
Memory T cells in transplantation - progress and challenges. Current opinion in organ transplantation. 2013 Information Resource GET IT
Times cited: 23
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 237
Activated mouse CD4(+)Foxp3(-) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity. Cell research. 2012 Academic Article GET IT
Times cited: 15
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nature immunology. 2012 Academic Article GET IT
Times cited: 193
Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 80
Memory T cells and their exhaustive differentiation in allograft tolerance and rejection. Current opinion in organ transplantation. 2012 Information Resource GET IT
Times cited: 21
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 80
Islet allograft tolerance in the absence of invariant natural killer T cells. Clinical immunology (Orlando, Fla.). 2011 Academic Article GET IT
Times cited: 2
Complement inhibition enables renal allograft accommodation and long-term engraftment in presensitized nonhuman primates. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2011 Academic Article GET IT
Times cited: 47
Blood loss during extensive escharectomy and auto-microskin grafting in adult male major burn patients. Burns : journal of the International Society for Burn Injuries. 2011 Academic Article GET IT
Times cited: 11
Regulatory T cells and the quest for transplant tolerance. Discovery medicine. 2011 Information Resource GET IT
Times cited: 11
Promotion of cutaneous wound healing by local application of mesenchymal stem cells derived from human umbilical cord blood. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2010 Academic Article GET IT
Times cited: 74
An update on regulatory T cells in transplant tolerance and rejection. Nature reviews. Nephrology. 2010 Information Resource GET IT
Times cited: 93
An overview on non-T cell pathways in transplant rejection and tolerance. Current opinion in organ transplantation. 2010 Information Resource GET IT
Times cited: 15
Structure and function of major histocompatibility complex class I antigens. Current opinion in organ transplantation. 2010 Information Resource GET IT
Times cited: 26
Regulatory T cells are critical to tolerance induction in presensitized mouse transplant recipients through targeting memory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2010 Academic Article GET IT
Times cited: 22
Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology (Baltimore, Md.). 2010 Academic Article GET IT
Times cited: 66
Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses. PloS one. 2010 Academic Article GET IT
Times cited: 28
Cross-immune tolerance: conception and its potential significance on transplantation tolerance. Cellular & molecular immunology. 2009 Information Resource GET IT
Times cited: 5
Inhibitory receptors of the immune system: functions and therapeutic implications. Cellular & molecular immunology. 2009 Information Resource GET IT
Times cited: 9
Inhalation injury in southwest China--the evolution of care. Burns : journal of the International Society for Burn Injuries. 2009 Academic Article GET IT
Times cited: 18
Costimulatory pathways in transplantation: challenges and new developments. Immunological reviews. 2009 Information Resource GET IT
Times cited: 147
OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 24
Antibacterial effect of dressings containing multivalent silver ion carried by zirconium phosphate on experimental rat burn wounds. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2008 Academic Article GET IT
Times cited: 7
OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 52
The innate natural killer cells in transplant rejection and tolerance induction. Current opinion in organ transplantation. 2008 Information Resource GET IT
Times cited: 44
OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ Tregs. Transplantation. 2008 Academic Article GET IT
Times cited: 36
The innate NK cells, allograft rejection, and a key role for IL-15. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 94
Novel roles of OX40 in the allograft response. Current opinion in organ transplantation. 2008 Information Resource GET IT
Times cited: 17
OX40 controls functionally different T cell subsets and their resistance to depletion therapy. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 55
Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4(+) and CD8(+) T cells in vivo. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2007 Academic Article GET IT
Times cited: 41
Approaches and challenges in targeting memory T cells in transplant tolerance. Archivum immunologiae et therapiae experimentalis. 2007 Information Resource GET IT
Times cited: 2
OX40 costimulation turns off Foxp3+ Tregs. Blood. 2007 Academic Article GET IT
Times cited: 344
Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 180
Critical, but conditional, role of OX40 in memory T cell-mediated rejection. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 97
Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection. Transplantation. 2005 Article GET IT
Times cited: 2
Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Academic Article GET IT
Times cited: 79
Study of T-cell costimulatory blockade in vivo at a single-cell level. Methods in molecular medicine. 2005 Academic Article GET IT
Times cited: 2
Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. The Journal of clinical endocrinology and metabolism. 2004 Academic Article GET IT
Times cited: 50
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 106
Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 39
The common gammac-cytokines and transplantation tolerance. Archivum immunologiae et therapiae experimentalis. 2004 Information Resource GET IT
Times cited: 2
The common gammac-cytokines and transplantation tolerance. Cellular & molecular immunology. 2004 Information Resource GET IT
Times cited: 5
Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 38
IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis. Cellular & molecular immunology. 2004 Academic Article GET IT
Times cited: 16
Critical role of OX40 in CD28 and CD154-independent rejection. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 101
Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms. Journal of immunology (Baltimore, Md. : 1950). 2003 Academic Article GET IT
Times cited: 13
Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation. 2003 Academic Article GET IT
Times cited: 123
Negative T cell costimulation and islet tolerance. Diabetes/metabolism research and reviews. 2003 Information Resource GET IT
Times cited: 19
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 21
Death of alloreactive T cells sets the stage for immunoregulation to act. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 2
The role of peripheral T-cell deletion in transplantation tolerance. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2001 Information Resource GET IT
Times cited: 33
T cell death and transplantation tolerance. Immunity. 2001 Information Resource GET IT
Times cited: 171
IL-15 and IL-2: a matter of life and death for T cells in vivo. Nature medicine. 2001 Academic Article GET IT
Times cited: 260
Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts. Transplantation. 2000 Academic Article GET IT
Times cited: 25
Rapamycin induces transforming growth factor-beta production by lymphocytes. Transplantation. 2000 Academic Article GET IT
Times cited: 32
The role of T cell apoptosis in transplantation tolerance. Current opinion in immunology. 2000 Information Resource GET IT
Times cited: 66
Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 72
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature medicine. 1999 Academic Article GET IT
Times cited: 635
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nature medicine. 1999 Academic Article GET IT
Times cited: 514
IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 60
Induction of allograft tolerance in the absence of Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 40
Selective antibody blockade of lymphocyte migration to mucosal sites and mast cell adhesion. Journal of leukocyte biology. 1999 Academic Article GET IT
Times cited: 14
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 149
Blood monocyte migration to acute lung inflammation involves both CD11/CD18 and very late activation antigen-4-dependent and independent pathways. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 53
Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment. Transplantation. 1998 Academic Article GET IT
Times cited: 122
On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 107
Differential expression of T-cell growth factors in rejecting murine islet and human renal allografts: conspicuous absence of interleukin (IL)-9 despite expression of IL-2, IL-4, IL-7, and IL-15. Transplantation. 1998 Academic Article GET IT
Times cited: 20
IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 85
Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 118
Expression of functional ICAM-1 and VCAM-1 adhesion molecules by an immortalized epithelial cell clone derived from the small intestine. Cellular immunology. 1997 Academic Article GET IT
Times cited: 24
Allogeneic lymphocyte proliferation stimulated by small intestine-derived epithelial cells. Transplantation. 1995 Academic Article GET IT
Times cited: 18
Donor-specific cytotoxicity induced by allogeneic intestinal epithelial cells in a sponge matrix model. Transplant international : official journal of the European Society for Organ Transplantation. 1995 Academic Article GET IT
Times cited: 2
Endotoxin in the peripheral blood during acute intestinal allograft rejection. Transplant international : official journal of the European Society for Organ Transplantation. 1994 Academic Article GET IT
Times cited: 5
Host immune suppression after small bowel/liver transplantation in rats. Transplant international : official journal of the European Society for Organ Transplantation. 1994 Academic Article GET IT
Times cited: 5
The effect of donor-recipient strain combination on rejection and graft-versus-host disease after small bowel/liver transplantation in the rat. Transplantation. 1993 Academic Article GET IT
Times cited: 23

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Background

education and training

Ph.D., University of Western Ontario (Canada) 1994
M.Sc., Qingdao University Medical College (China) 1986

Contact

full name

Xian Li

VIVO Weill Cornell Medical College

Xian Li Professor of Immunology in Surgery

Publications

selected publications

Background

education and training

Contact

full name