selected publications
- Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature communications. 2023 Academic Article GET IT
- Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer cell. 2022 Academic Article GET IT
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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Molecular cell.
2021
Academic Article
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Times cited: 11 - PKCl/i inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Molecular cell. 2021 Academic Article
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Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.
Cell.
2020
Academic Article
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Times cited: 13 -
Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration.
JCI insight.
2020
Academic Article
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Times cited: 17 -
LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome.
Cell death & disease.
2020
Academic Article
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Times cited: 18 -
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.
Cancer research.
2019
Academic Article
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Times cited: 21 -
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.
Science (New York, N.Y.).
2019
Academic Article
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Times cited: 112 -
Receptor-mediated endocytosis generates nanomechanical force reflective of ligand identity and cellular property.
Journal of cellular physiology.
2018
Academic Article
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Times cited: 9 - Formation of Giant Lysosome in Neonatal Ileal Enterocytes Requires Endotubin. Cellular and molecular gastroenterology and hepatology. 2017 Editorial Article GET IT
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A Wntless-SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export.
Journal of cell science.
2017
Academic Article
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Times cited: 21 - Intestinal GPCRs Control Paneth Cell Maturation and Susceptibility to Experimental Colitis. Cellular and molecular gastroenterology and hepatology. 2016 Editorial Article GET IT
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CDC42 inhibition suppresses progression of incipient intestinal tumors.
Cancer research.
2014
Academic Article
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Times cited: 46