selected publications
- Long-term 3D cell culture models for hepatitis B virus studies. Virology. 2024 Academic Article GET IT
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Optimizing liver health before and after gene therapy for hemophilia A.
Blood advances.
2024
Review
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Times cited: 3 - Mice Engrafted with Human Liver Cells. Seminars in liver disease. 2024 Review GET IT
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Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1.
Cancer research.
2024
Academic Article
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Times cited: 2 -
Innate Immune Sensing of Adeno-Associated Virus Vectors.
Human gene therapy.
2024
Review
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Times cited: 6 - Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription. Cell. 2024 Academic Article GET IT
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TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
Molecular therapy : the journal of the American Society of Gene Therapy.
2023
Academic Article
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Times cited: 10 -
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.
Nature cancer.
2023
Academic Article
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Times cited: 10 -
An RNA-based system to study hepatitis B virus replication and evaluate antivirals.
Science advances.
2023
Academic Article
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Times cited: 5 -
Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion.
Human gene therapy.
2023
Academic Article
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Times cited: 4 -
Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022
Academic Article
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Times cited: 18 -
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice.
Cell reports.
2022
Academic Article
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Times cited: 14 -
Targeting BCL-XL in fibrolamellar hepatocellular carcinoma.
JCI insight.
2022
Academic Article
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Times cited: 13 -
AAV and hepatitis: Cause or coincidence?.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022
Editorial Article
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Times cited: 8 -
IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy.
2022
Academic Article
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Times cited: 26 - Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States. Cancer medicine. 2021 Academic Article GET IT
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RNR-R2 Upregulation by a Short Non-Coding Viral Transcript.
Biomolecules.
2021
Academic Article
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Times cited: 2 -
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening.
Cancer discovery.
2021
Academic Article
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Times cited: 29 - Primary human hepatocyte gene editing: Prometheus' chains are loosening. Molecular therapy : the journal of the American Society of Gene Therapy. 2021 Comment GET IT
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Liver gene therapy and hepatocellular carcinoma: A complex web.
Molecular therapy : the journal of the American Society of Gene Therapy.
2021
Editorial Article
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Times cited: 17 -
Single-Cell Sorting of HBsAg-Binding Memory B Cells from Human Peripheral Blood Mononuclear Cells and Antibody Cloning.
STAR protocols.
2020
Academic Article
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Times cited: 7 -
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity.
Molecular therapy. Methods & clinical development.
2020
Academic Article
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Times cited: 23 -
Microthrombosis associated with GI bleeding in COVID-19.
2020
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Times cited: 6 -
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations.
Cell host & microbe.
2020
Academic Article
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Times cited: 50 -
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice.
Molecular therapy. Methods & clinical development.
2020
Academic Article
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Times cited: 19 - Stem cell-derived HCV infection systems illustrate the bright future of human hepatocyte research. Gut. 2020 Comment GET IT
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Immune Responses to Viral Gene Therapy Vectors.
Molecular therapy : the journal of the American Society of Gene Therapy.
2020
Review
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Times cited: 484 -
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 42 -
Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP).
Journal of virology.
2019
Academic Article
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Times cited: 74 -
Inherited IL-18BP deficiency in human fulminant viral hepatitis.
2019
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Times cited: 49 -
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.
Cell.
2018
Academic Article
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Times cited: 173 -
Hepatitis C Virus Neutralizing Antibodies: Is a Vaccine Still Possible?.
Cell host & microbe.
2018
Comment
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Times cited: 1 - Modeling Unique Patients in Humanized Mice: Toward a Curative Strategy for HIV. Molecular therapy : the journal of the American Society of Gene Therapy. 2018 Editorial Article GET IT
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A robust cell culture system supporting the complete life cycle of hepatitis B virus.
Scientific reports.
2017
Academic Article
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Times cited: 63 -
Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice.
Cellular and molecular gastroenterology and hepatology.
2017
Academic Article
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Times cited: 8 -
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.
Science translational medicine.
2017
Academic Article
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Times cited: 132 -
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
Immunity.
2017
Academic Article
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Times cited: 86 -
The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.
Molecular therapy : the journal of the American Society of Gene Therapy.
2017
Academic Article
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Times cited: 58 -
Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer.
Molecular therapy. Methods & clinical development.
2016
Academic Article
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Times cited: 33 -
Fibrosis Progression in Patients With Chronic Hepatitis C Virus Infection.
The Journal of infectious diseases.
2016
Academic Article
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Times cited: 25 -
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells.
Journal of hepatology.
2016
Academic Article
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Times cited: 70 -
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.
Molecular therapy : the journal of the American Society of Gene Therapy.
2016
Academic Article
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Times cited: 91 -
Animal models for the study of HCV.
Current opinion in virology.
2015
Review
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Times cited: 25 -
Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice.
Hepatology (Baltimore, Md.).
2015
Academic Article
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Times cited: 21 -
Hepatitis C virus RNA functionally sequesters miR-122.
Cell.
2015
Academic Article
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Times cited: 280 -
HCV animal models and liver disease.
Journal of hepatology.
2014
Review
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Times cited: 31 -
Broadly neutralizing antibodies abrogate established hepatitis C virus infection.
Science translational medicine.
2014
Academic Article
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Times cited: 195 -
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 213 -
Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma.
Seminars in cancer biology.
2014
Review
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Times cited: 140 -
Antisense therapy for hepatitis C virus infection.
Journal of hepatology.
2013
Comment
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Times cited: 11 -
Emerging therapeutic targets for hepatitis C virus infection.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2013
Review
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Times cited: 14 -
Animal models for hepatitis C.
Current topics in microbiology and immunology.
2013
Review
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Times cited: 69 -
Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice.
Journal of hepatology.
2010
Editorial Article
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Times cited: 4 -
New horizons for studying human hepatotropic infections.
The Journal of clinical investigation.
2010
Comment
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Times cited: 44 -
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Cell host & microbe.
2009
Review
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Times cited: 184 -
Use of spoligotyping and large sequence polymorphisms to study the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive smear-positive tuberculosis cases in The Gambia.
Journal of clinical microbiology.
2009
Academic Article
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Times cited: 50 -
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.
Nature.
2009
Academic Article
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Times cited: 790 -
In vivo generation of oligoclonal colitic CD4+ T-cell lines expressing a distinct T-cell receptor Vbeta.
Gastroenterology.
2005
Academic Article
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Times cited: 4 -
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery.
Gastroenterology.
2004
Academic Article
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Times cited: 38 -
Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation.
Immunity.
2004
Academic Article
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Times cited: 114 -
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.
International immunology.
2004
Academic Article
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Times cited: 31 -
Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation.
International immunology.
2003
Academic Article
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Times cited: 20 -
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
Gastroenterology.
2002
Academic Article
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Times cited: 168 -
Development of chronic colitis is dependent on the cytokine MIF.
Nature immunology.
2001
Academic Article
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Times cited: 266 -
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice.
Gastroenterology.
2001
Academic Article
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Times cited: 109 -
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration.
Gastroenterology.
2000
Academic Article
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Times cited: 84 -
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice.
Gastroenterology.
2000
Academic Article
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Times cited: 174 -
Pathways of T cell pathology in models of chronic intestinal inflammation.
International reviews of immunology.
2000
Review
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Times cited: 9 -
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America.
1999
Academic Article
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Times cited: 40 -
Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease.
Gastroenterology.
1998
Academic Article
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Times cited: 21 -
Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.
Inflammatory bowel diseases.
1998
Academic Article
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Times cited: 30 -
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells.
The Journal of experimental medicine.
1998
Academic Article
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Times cited: 256 -
T cells in mouse models of gut inflammation.
Chemical immunology.
1998
Review
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Times cited: 7 -
Interleukin 8 released after acute myocardial infarction is mainly bound to erythrocytes.
Heart (British Cardiac Society).
1997
Academic Article
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Times cited: 40