Chen, Yu

Publications

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selected publications

The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence. Science signaling. 2024 Review GET IT
MEK inhibitors lead to PDGFR pathway upregulation and sensitize tumors to RAF dimer inhibitors in NF1-deficient malignant peripheral nerve sheath tumor (MPNST). Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
Clinical, Imaging, and Technical Factors Associated with Successful Genomic Profiling of Bone Biopsy Tissue in Prostate Cancer. European urology oncology. 2024 Academic Article GET IT
Publisher Correction: Sex differences orchestrated by androgens at single-cell resolution. 2024 GET IT
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting. PloS one. 2024 Academic Article GET IT
Sex differences orchestrated by androgens at single-cell resolution. Nature. 2024 Academic Article GET IT
Times cited: 1
ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Cancer discovery. 2024 Academic Article GET IT
Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer. Science advances. 2023 Academic Article GET IT
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. 2022 GET IT
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. Nature communications. 2022 Academic Article GET IT
Times cited: 18
XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Editorial Article GET IT
Gene-based Confirmatory Germline Testing Following Tumor-only Sequencing of Prostate Cancer. European urology. 2022 Academic Article GET IT
Times cited: 1
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Science (New York, N.Y.). 2022 Academic Article GET IT
Times cited: 129
PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer discovery. 2022 Academic Article GET IT
Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 22
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science (New York, N.Y.). 2022 Academic Article GET IT
Characterization of stage-specific tumor progression in TMPRSS2-ERG (fusion)-driven and non-fusion-driven prostate cancer in GEM models. Molecular carcinogenesis. 2022 Academic Article GET IT
Times cited: 6
Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors (GIST). Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Molecular Imaging of Neuroendocrine Prostate Cancer by Targeting Delta-Like Ligand 3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 Academic Article GET IT
Times cited: 22
Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer. Oncogene. 2021 Academic Article GET IT
Times cited: 8
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers. Nature communications. 2021 Academic Article GET IT
Times cited: 16
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nature communications. 2021 Academic Article GET IT
Times cited: 74
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. Cancer cell. 2021 Academic Article GET IT
Times cited: 9
Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 22
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity. Nature communications. 2020 Academic Article GET IT
Times cited: 76
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 30
Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer. JCO precision oncology. 2020 Academic Article GET IT
Times cited: 37
Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment. Cancer research. 2020 Academic Article GET IT
Times cited: 11
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips. Nature genetics. 2020 Academic Article GET IT
Times cited: 88
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 35
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2. Cancer research. 2020 Academic Article GET IT
Times cited: 11
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Comment GET IT
Times cited: 79
Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature. 2019 Academic Article GET IT
Times cited: 146
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO molecular medicine. 2019 Academic Article GET IT
Times cited: 63
PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 57
The androgen receptor regulates a druggable translational regulon in advanced prostate cancer. Science translational medicine. 2019 Academic Article GET IT
Times cited: 46
Aberrant Expression of ERG Promotes Resistance to Combined PI3K and AR Pathway Inhibition through Maintenance of AR Target Genes. Molecular cancer therapeutics. 2019 Academic Article GET IT
Times cited: 11
CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis. Cancer cell. 2019 Academic Article GET IT
Times cited: 64
Patient derived organoids to model rare prostate cancer phenotypes. Nature communications. 2018 Academic Article GET IT
Times cited: 260
TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 51
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer. EMBO molecular medicine. 2018 Academic Article GET IT
Times cited: 40
A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer. Investigational new drugs. 2018 Academic Article GET IT
Times cited: 61
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 34
GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell reports. 2018 Academic Article GET IT
Times cited: 58
SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 27
FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer discovery. 2017 Academic Article GET IT
Times cited: 50
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer cell. 2017 Academic Article GET IT
Times cited: 58
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nature medicine. 2017 Academic Article GET IT
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature medicine. 2017 Academic Article GET IT
Times cited: 244
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Academic Article GET IT
Times cited: 1294
ETV1-Positive Cells Give Rise to BRAF^V600E -Mutant Gastrointestinal Stromal Tumors. Cancer research. 2017 Academic Article GET IT
Times cited: 13
The potential of organoids in urological cancer research. Nature reviews. Urology. 2017 Information Resource GET IT
Times cited: 73
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer cell. 2017 Academic Article GET IT
Times cited: 151
Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Disease models & mechanisms. 2016 Academic Article GET IT
Times cited: 31
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer cell. 2016 Academic Article GET IT
Times cited: 399
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PloS one. 2016 Academic Article GET IT
Times cited: 20
A Computational Drug Repositioning Approach for Targeting Oncogenic Transcription Factors. Cell reports. 2016 Academic Article GET IT
Times cited: 29
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nature genetics. 2016 Academic Article GET IT
Times cited: 229
Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair. Oncotarget. 2016 Academic Article GET IT
Times cited: 31
Organoid culture systems for prostate epithelial and cancer tissue. Nature protocols. 2016 Academic Article GET IT
Times cited: 465
The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015 Academic Article GET IT
Times cited: 2287
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Academic Article GET IT
Times cited: 190
Integrative clinical genomics of advanced prostate cancer. Cell. 2015 Academic Article GET IT
Times cited: 2535
Organoid development in cancer genome discovery. Current opinion in genetics & development. 2015 Information Resource GET IT
Times cited: 60
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer discovery. 2015 Academic Article GET IT
Times cited: 114
Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling. Molecular cancer therapeutics. 2014 Academic Article GET IT
Times cited: 30
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nature genetics. 2014 Academic Article GET IT
Times cited: 462
Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 Academic Article GET IT
Times cited: 576
Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Academic Article GET IT
Times cited: 1161
Effect of margin width on local recurrence in triple-negative breast cancer patients treated with breast-conserving therapy. Annals of surgical oncology. 2013 Academic Article GET IT
Times cited: 35
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer discovery. 2013 Academic Article GET IT
Times cited: 430
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nature medicine. 2013 Academic Article GET IT
Times cited: 237
Overcoming mutation-based resistance to antiandrogens with rational drug design. eLife. 2013 Academic Article GET IT
Times cited: 335
β4 Integrin signaling induces expansion of prostate tumor progenitors. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 80
ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer research. 2012 Academic Article GET IT
Times cited: 587
Prostate cancer in 2011: Hitting old targets better and identifying new targets. Nature reviews. Clinical oncology. 2012 Information Resource GET IT
Times cited: 13
Visualization of the interstitial cells of cajal (ICC) network in mice. Journal of visualized experiments : JoVE. 2011 Academic Article GET IT
Times cited: 13
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer cell. 2011 Academic Article GET IT
Times cited: 995
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature. 2010 Academic Article GET IT
Times cited: 268
Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 1913
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer research. 2009 Academic Article GET IT
Times cited: 160
Targeting the androgen receptor pathway in prostate cancer. Current opinion in pharmacology. 2008 Information Resource GET IT
Times cited: 346
In vivo analysis of human multidrug resistance protein 1 (MRP1) activity using transient expression of fluorescently tagged MRP1. Cancer research. 2002 Academic Article GET IT
Times cited: 39
In situ biochemical demonstration that P-glycoprotein is a drug efflux pump with broad specificity. The Journal of cell biology. 2000 Academic Article GET IT
Times cited: 52
Tamoxifen inhibits acidification in cells independent of the estrogen receptor. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 106
Defective acidification in human breast tumor cells and implications for chemotherapy. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 254

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Background

education and training

M.D., Cornell University Medical College 2002
Ph.D., The Rockefeller University 2001
A.B., Princeton University 1993

Contact

full name

Yu Chen

primary email

cheny1@mskcc.org

VIVO Weill Cornell Medical College

Yu Chen Associate Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email