Science translational medicine

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Local changes in network structure contribute to late communication recovery after severe brain injury. 2016
Erratum for the Research Article: "Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia" by Y. Lim, L. Gondek, L. Li, Q. Wang, H. Ma, E. Chang, D. L. Huso, S. Foerster, L. Marchionni, K. McGovern, D. N. Watkins, C. D. Peacock, M. Levis, B. D. Smith, A. A. Merchant, D. Small, W. Matsui. 2015
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques.. 17. 2025
Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.. 16. 2024
Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration.. 16. 2024
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.. 16. 2024
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption.. 16. 2024
Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.. 16. 2024
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.. 15. 2023
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.. 15. 2023
Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse.. 15. 2023
Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma.. 15. 2023
Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer.. 15. 2023
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.. 15. 2023
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes.. 15. 2023
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration.. 15. 2023
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later. 2022
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency.. 14. 2022
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery.. 14. 2022
Adenoviral-based vaccine promotes neoantigen-specific CD8⁺ T cell stemness and tumor rejection.. 14. 2022
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.. 14. 2022
MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT.. 14. 2022
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.. 14. 2022
Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia.. 14. 2022
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.. 14. 2022
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence.. 13. 2021
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.. 13. 2021
Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected.. 13. 2021
Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy.. 13. 2021
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade.. 13. 2021
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice.. 13. 2021
First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes.. 13. 2021
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity.. 13. 2021
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.. 12. 2020
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2.. 12. 2020
Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans.. 12. 2020
Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.. 12. 2020
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.. 12. 2020
Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy.. 12. 2020
Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies.. 12. 2020
DNA vaccination before conception protects Zika virus-exposed pregnant macaques against prolonged viremia and improves fetal outcomes.. 11. 2019
A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough.. 11. 2019
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment.. 11. 2019
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.. 11. 2019
CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies.. 11. 2019
Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.. 11. 2019
Overcoming adaptive therapy resistance in AML by targeting immune response pathways.. 11. 2019
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species.. 11. 2019
The androgen receptor regulates a druggable translational regulon in advanced prostate cancer.. 11. 2019
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.. 11. 2019
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.. 11. 2019
Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease.. 11. 2019
Primary cilia defects causing mitral valve prolapse.. 11. 2019
HBEGF⁺ macrophages in rheumatoid arthritis induce fibroblast invasiveness.. 11. 2019
GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.. 11. 2019
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.. 11. 2019
Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.. 11. 2019
Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity.. 10. 2018
Mixed-effects association of single cells identifies an expanded effector CD4⁺ T cell subset in rheumatoid arthritis.. 10. 2018
An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo.. 10. 2018
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals.. 10. 2018
Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant.. 10. 2018
Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag.. 10. 2018
A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.. 10. 2018
MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma.. 10. 2018
Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.. 10. 2018
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice.. 10. 2018
Targeting protein biotinylation enhances tuberculosis chemotherapy.. 10. 2018
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.. 10. 2018
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8.. 10. 2018
Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.. 9. 2017
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.. 9. 2017
Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis.. 9. 2017
Genomic profiling of ER⁺ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.. 9. 2017
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.. 9. 2017
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.. 9. 2017
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.. 9. 2017
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.. 9. 2017
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.. 9. 2017
Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets.. 9. 2017
IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote T_H17-dependent inflammation.. 9. 2017
CD99 is a therapeutic target on disease stem cells in myeloid malignancies.. 9. 2017
Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.. 9. 2017
Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis.. 8. 2016
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.. 8. 2016
Maternal HIV infection influences the microbiome of HIV-uninfected infants.. 8. 2016
P-selectin is a nanotherapeutic delivery target in the tumor microenvironment.. 8. 2016
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.. 8. 2016
Somatic PIK3CA mutations as a driver of sporadic venous malformations.. 8. 2016
Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury.. 8. 2016
Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment.. 8. 2016
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.. 8. 2016
TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.. 8. 2016
CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.. 8. 2016
Immune history profoundly affects broadly protective B cell responses to influenza.. 7. 2015
Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.. 7. 2015
Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer.. 7. 2015
TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL.. 7. 2015
Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer.. 7. 2015
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.. 7. 2015
Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis.. 7. 2015
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.. 7. 2015
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.. 7. 2015
Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.. 7. 2015
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.. 7. 2015
Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.. 7. 2015
Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep.. 6. 2014
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity.. 6. 2014
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.. 6. 2014
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe.. 6. 2014
Broadly neutralizing antibodies abrogate established hepatitis C virus infection.. 6. 2014
Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia.. 6. 2014
Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.. 6. 2014
Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody.. 6. 2014
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy.. 6. 2014
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia.. 6. 2014
Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer.. 5. 2013
PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses.. 5. 2013
Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.. 5. 2013
Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome.. 5. 2013
mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.. 5. 2013
Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.. 5. 2013
CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia.. 5. 2013
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination.. 5. 2013
Targeting the intracellular WT1 oncogene product with a therapeutic human antibody.. 5. 2013
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans.. 5. 2013
Lineage structure of the human antibody repertoire in response to influenza vaccination.. 5. 2013
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.. 5. 2013
Pazopanib enhances paclitaxel-induced mitotic catastrophe in anaplastic thyroid cancer.. 5. 2013
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients.. 4. 2012
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.. 4. 2012
AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation.. 4. 2012
Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile.. 4. 2012
Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.. 4. 2012
Notch4 normalization reduces blood vessel size in arteriovenous malformations.. 4. 2012
Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.. 4. 2012
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration.. 3. 2011
Preclinical and clinical evaluation of intraductally administered agents in early breast cancer.. 3. 2011
A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms.. 3. 2011
Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma.. 3. 2011
Biomedical innovation: a risky business at risk.. 3. 2011
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.. 3. 2011
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma.. 3. 2011
In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins.. 3. 2011
Breast cancer methylomes establish an epigenomic foundation for metastasis.. 3. 2011
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.. 3. 2011
TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis.. 2. 2010
Metabolic syndromes and malignant transformation: where the twain shall meet.. 2. 2010
Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens.. 2. 2010
Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model.. 1. 2009
Antisense gets a grip on miR-122 in chimpanzees.. 2. 2010
Comment on "ALK is a therapeutic target for lethal sepsis". 2018
The clone wars. 2017
Unleashing the wrath of Ras. 2017
Synthetic lethality and beyond. 2016
Making waves in consciousness research. 2013
Cup of Joe: a brain development "no"? 2013
Treg cells in cancer: a case of multiple personality disorder. 2012
ICOStomizing immunotherapies with T(H)17. 2010
Comment on "the predictive capacity of personal genome sequencing". 2012
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. 2015
Biology of antimicrobial resistance and approaches to combat it. 2020
On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation. 2015
Fresh approaches to anti-infective therapies. 2012
Fusion peptide-directed antibodies: Humoral armor against HIV-1 infection. 2024
The hallmarks of successful anticancer immunotherapy. 2018
Cancer metabolism gets physical. 2018
Imaging approaches to optimize molecular therapies. 2016
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. 2016

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