Neurobiology of disease

publication venue for

Time- and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus.. 187. 2023
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. 186. 2023
Uncovering a neurological protein signature for severe COVID-19.. 182. 2023
The effect of aquaporin-4 mis-localization on Aβ deposition in mice.. 181. 2023
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease.. 174. 2022
Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy. 2022
Association between lower body temperature and increased tau pathology in cognitively normal older adults. 2022
CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy.. 158. 2021
Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy.. 151. 2021
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology.. 146. 2020
Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients.. 144. 2020
The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.. 136. 2020
Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma.. 134. 2019
Ex vivo multi-electrode analysis reveals spatiotemporal dynamics of ictal behavior at the infiltrated margin of glioma.. 134. 2019
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA_A receptors.. 134. 2019
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.. 127. 2019
Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.. 121. 2018
Istradefylline reduces memory deficits in aging mice with amyloid pathology.. 110. 2017
Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model.. 96. 2016
Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability.. 93. 2016
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.. 86. 2015
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy.. 85. 2015
Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease.. 82. 2015
The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals.. 82. 2015
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.. 74. 2014
18FDG-microPET and MR DTI findings in Tor1a+/- heterozygous knock-out mice.. 73. 2014
Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.. 74. 2014
A study of the role of the FOXP2 and CNTNAP2 genes in persistent developmental stuttering.. 69. 2014
An increase in MECP2 dosage impairs neural tube formation.. 67. 2014
A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.. 49. 2012
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms.. 48. 2012
Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.. 48. 2012
In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins.. 45. 2011
Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.. 43. 2011
The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production.. 42. 2011
Early Parkinson's disease: longitudinal changes in brain activity during sequence learning.. 37. 2009
Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.. 36. 2009
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo.. 36. 2009
Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.. 34. 2008
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.. 31. 2008
Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway.. 29. 2007
CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.. 26. 2007
Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.. 26. 2007
Basal ganglia lesions after MPTP administration in rhesus monkeys.. 23. 2006
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.. 20. 2005
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice.. 21. 2005
Amygdaloid kindled seizures can induce functional and pathological changes in thymus of rat: role of the sympathetic nervous system.. 21. 2005
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.. 19. 2005
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.. 16. 2004
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.. 9. 2002
T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis.. 6. 1999
Local cerebral blood flow during the first hour following acute ligation of multiple arterioles in rat whisker barrel cortex.. 5. 1998
Genes and the long and winding road to cortical construction and cognition.. 38. 2010
Multiscale recordings reveal the dynamic spatial structure of human seizures. 2019
Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging. 2018
Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis. 2015
Hospitalization and psychosis: influences on the course of cognition and everyday functioning in people with schizophrenia. 2012
Hereditary dystonia as a neurodevelopmental circuit disorder: Evidence from neuroimaging. 2010
Network biomarkers for the diagnosis and treatment of movement disorders. 2008
Biomarkers of Alzheimer's disease. 2008
Leveraging animal models to understand non-motor symptoms of Parkinson's disease. 2025
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. 2022
To target Tau pathologies, we must embrace and reconstruct their complexities. 2021
Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein. 2021
Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases. 2020
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports. 2020
Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs. 2019
Deep brain stimulation in the treatment of refractory epilepsy: update on current data and future directions. 2009

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Neurobiology of disease Journal

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