Chemistry & biology
Journal
Overview
publication venue for
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In-gel imaging of RNA processing using broccoli reveals optimal aptamer expression strategies..
22.
2015
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Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism..
22.
2015
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Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis..
22.
2014
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eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes..
21.
2014
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Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis..
21.
2014
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Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification..
20.
2013
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Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons..
20.
2013
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A designed inhibitor of a CLC antiporter blocks function through a unique binding mode..
19.
2012
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Chemical genetic-mediated spatial regulation of protein expression in neurons reveals an axonal function for wld(s)..
19.
2012
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Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis..
18.
2011
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Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators..
18.
2011
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Assembling ligands in situ using bioorthogonal boronate ester synthesis..
17.
2010
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Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates..
17.
2010
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Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase..
17.
2010
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Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation..
17.
2010
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Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity..
17.
2010
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Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis..
16.
2009
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Nitrosothiol reactivity profiling identifies S-nitrosylated proteins with unexpected stability..
15.
2008
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Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation..
15.
2007
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Native chemical ligation in covalent caspase inhibition by p35..
13.
2006
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Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity..
12.
2005
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Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP..
11.
2004
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Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90..
11.
2004
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Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity..
11.
2004
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Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter..
11.
2004
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Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR..
10.
2003
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Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue..
9.
2002
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A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells..
8.
2001
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Chemical synthesis and biological properties of pyridine epothilones..
7.
2000
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Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.
2015
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Probing translation with small-molecule inhibitors.
2010
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Mining the metabiome: identifying novel natural products from microbial communities.
2014
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