FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid.. 37. 2023
Increased Ca²⁺ signaling through Ca_V 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.. 37. 2023
Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail.. 37. 2023
Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function.. 36. 2022
The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.. 35. 2021
Polycystin-1 regulates cardiomyocyte mitophagy.. 35. 2021
Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.. 35. 2021
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.. 35. 2021
hnRNP K supports the maintenance of RORγ circadian rhythm through ERK signaling.. 35. 2021
GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.. 34. 2020
Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.. 34. 2020
Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy.. 34. 2020
Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.. 34. 2019
A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering.. 34. 2019
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.. 33. 2019
MicroRNA-31-5p enhances the Warburg effect via targeting FIH.. 33. 2018
The Mfge8-α8β1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation. 2018
Response gene to complement 32 suppresses adipose tissue thermogenic genes through inhibiting β3-adrenergic receptor/mTORC1 signaling.. 32. 2018
Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia.. 32. 2018
The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.. 32. 2018
IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue.. 32. 2018
Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.. 32. 2018
Connexin-purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation.. 31. 2017
Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.. 30. 2016
Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts.. 30. 2016
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.. 30. 2016
A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function.. 29. 2015
Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.. 29. 2015
Absence of nicotinic acetylcholine receptor α7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model.. 29. 2015
Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice.. 29. 2015
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells.. 29. 2015
The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.. 29. 2014
E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role.. 29. 2014
A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.. 28. 2014
Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.. 28. 2014
Kcne3 deletion initiates extracardiac arrhythmogenesis in mice.. 28. 2013
Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation.. 28. 2013
A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels.. 28. 2013
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies.. 28. 2013
The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation.. 27. 2013
A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1).. 27. 2012
Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema.. 27. 2012
Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.. 26. 2012
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging.. 26. 2012
Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.. 26. 2012
The dynamic range of the human metabolome revealed by challenges.. 26. 2012
Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism.. 26. 2012
EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.. 26. 2011
Opposing roles of RAGE and Myd88 signaling in extensive liver resection.. 26. 2011
HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation.. 26. 2011
MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.. 25. 2011
Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase.. 25. 2011
Regulation of female reproduction by p53 and its family members.. 25. 2011
Physiological loading of joints prevents cartilage degradation through CITED2.. 25. 2010
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.. 24. 2010
p21cip/WAF is a key regulator of long-term radiation damage in mesenchyme-derived tissues.. 24. 2010
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.. 24. 2010
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia.. 24. 2010
Polylactide-cyclosporin A nanoparticles for targeted immunosuppression.. 24. 2010
Regulation of homocysteine metabolism and methylation in human and mouse tissues.. 24. 2010
Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation.. 24. 2010
Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.. 24. 2009
Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.. 24. 2009
Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.. 23. 2009
Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease.. 23. 2009
Multimodality imaging of TGFbeta signaling in breast cancer metastases.. 23. 2009
Signaling mechanism of extracellular RNA in endothelial cells.. 23. 2009
Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.. 23. 2009
Functional analysis of monocyte MHC class II compartments.. 23. 2008
Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death.. 23. 2008
The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity.. 22. 2008
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.. 22. 2008
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).. 22. 2008
Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats.. 22. 2008
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.. 22. 2008
Attenuated multimutated herpes simplex virus-1 effectively treats prostate carcinomas with neural invasion while preserving nerve function.. 22. 2008
Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.. 22. 2007
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling.. 21. 2007
Plastic cells and populations: DNA substrate characteristics in Helicobacter pylori transformation define a flexible but conservative system for genomic variation.. 21. 2007
Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo.. 21. 2007
A paradigm for direct stress-induced mutation in prokaryotes.. 20. 2006
Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia.. 20. 2006
Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.. 20. 2006
Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.. 20. 2006
Prodynorphin storage and processing in axon terminals and dendrites.. 20. 2006
Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.. 20. 2006
In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells.. 20. 2006
Real-time diagnostic imaging of tumors and metastases by use of a replication-competent herpes vector to facilitate minimally invasive oncological surgery.. 20. 2006
Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization.. 20. 2006
The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication.. 20. 2006
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.. 20. 2005
Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts.. 20. 2005
Blood-brain barrier-specific properties of a human adult brain endothelial cell line.. 19. 2005
A central role for ceramide in the age-related acceleration of apoptosis in the female germline.. 19. 2005
Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts.. 19. 2005
Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells.. 19. 2005
Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation.. 18. 2004
Transcriptional changes following restoration of SERCA2a levels in failing rat hearts.. 18. 2004
Apoptosis signals in lymphoblasts induced by focused ultrasound.. 18. 2004
Caveolae compartmentalization of heme oxygenase-1 in endothelial cells.. 18. 2004
Up-regulation of GADD34 mediates the synergistic anticancer activity of mitomycin C and a gamma134.5 deleted oncolytic herpes virus (G207).. 18. 2004
Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver.. 18. 2004
Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth.. 18. 2004
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease.. 18. 2003
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains.. 17. 2002
Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion.. 16. 2002
Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model.. 15. 2001
Physiological cyclic stretch directs L-arginine transport and metabolism to collagen synthesis in vascular smooth muscle.. 14. 2000
Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207).. 13. 1999
Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate.. 12. 1998
Leptin regulates proinflammatory immune responses.. 12. 1998
Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia.. 11. 1997
Interleukin-1beta, tumor necrosis factor-alpha, and LPS enhance calcium channel current in isolated vascular smooth muscle cells of rat tail artery.. 10. 1996
Calcium mediates expression of stress-response genes in prostaglandin A2-induced growth arrest.. 8. 1994
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs.. 5. 1991
How do disclosure policies fail? Let us count the ways.. 23. 2009
"Taking the waters"--springs, wells, and spas.. 21. 2007
The sopranos: post-op virtuosi.. 20. 2006
Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal. 1996
Applications of ratio fluorescence microscopy in the study of cell physiology. 1994
Role of the CD45 tyrosine phosphatase in signal transduction in the immune system. 1993
Nitric oxide as a secretory product of mammalian cells. 1992
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. 1991
Complex and diversified regulatory programs control the expression of vertebrate collagen genes. 1990
Role of protein phosphorylation in neuronal signal transduction. 1989
NMR spectroscopy as an investigative technique in physiology. 1987
Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. 1996
Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network. 1992
Regulation of renal ion channels. 1988

VIVO Weill Cornell Medical College

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