ACS medicinal chemistry letters
Journal
Overview
publication venue for
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AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity..
17.
2026
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Virtual Screening-Guided Discovery of Small-Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids..
16.
2025
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Design, Synthesis, and Cellular Efficacy of Inositol-Requiring Enzyme Type 1 (IRE1α) Inhibitors..
16.
2025
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Discovery of Novel Isofunctional SARS-CoV‑2 NSP14 RNA Cap Methyltransferase Inhibitors by Structure-Based Virtual Screening..
16.
2025
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Discovery of a Small Molecule TREM2 Agonist with Improved In Vitro Pharmacokinetic Profile and Validated Target Engagement..
16.
2025
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From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3..
15.
2024
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Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability..
15.
2024
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Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors..
15.
2024
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Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055..
15.
2024
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Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas..
14.
2023
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Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)..
14.
2023
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An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline..
13.
2022
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A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors..
13.
2022
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Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)..
12.
2021
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Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling..
11.
2020
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Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family..
11.
2020
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Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage..
11.
2020
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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma..
11.
2020
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Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides..
10.
2019
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New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons..
9.
2018
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Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase..
9.
2018
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Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis..
9.
2018
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Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator..
9.
2018
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18F-Radiolabeled Panobinostat Allows for Positron Emission Tomography Guided Delivery of a Histone Deacetylase Inhibitor..
9.
2018
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Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents..
5.
2014
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Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome..
5.
2014
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Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation..
4.
2013
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Design, synthesis, and evaluation of prodrugs of ertapenem..
4.
2013
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Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis..
2.
2011
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Correction to "An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline"..
14.
2023
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