Genes & development
Journal
Overview
publication venue for
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Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface.
2023
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An integrated SAGA and TFIID PIC assembly pathway selective for poised and induced promoters..
36.
2022
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YTHDC2 control of gametogenesis requires helicase activity but not m6A binding.
2022
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Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes.
2021
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Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas..
35.
2021
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MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling..
34.
2020
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Recurrent SRSF2 mutations in MDS affect both splicing and NMD..
34.
2020
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Regulation of histone methylation by automethylation of PRC2..
33.
2019
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Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia..
33.
2019
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Endoreduplication of the mouse genome in the absence of ORC1..
32.
2018
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PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia..
32.
2018
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Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma..
32.
2018
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Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming..
31.
2017
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Dynamic assembly and activation of estrogen receptor α enhancers through coregulator switching..
31.
2017
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Hormone-dependent control of developmental timing through regulation of chromatin accessibility..
31.
2017
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The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue..
30.
2016
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Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss..
30.
2015
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Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing..
29.
2015
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Molecular mechanisms of ribosomal protein gene coregulation..
29.
2015
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CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma..
28.
2014
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Two waves of de novo methylation during mouse germ cell development..
28.
2014
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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase..
28.
2014
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How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes..
28.
2014
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D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice..
28.
2014
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Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging..
28.
2014
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The Rad50 hook domain regulates DNA damage signaling and tumorigenesis..
28.
2014
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A modular and flexible ESC-based mouse model of pancreatic cancer..
28.
2014
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Induction of sarcomas by mutant IDH2..
27.
2013
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Chaperone-mediated autophagy degrades mutant p53..
27.
2013
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A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival..
27.
2013
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Survival factor NFIL3 restricts FOXO-induced gene expression in cancer..
27.
2013
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ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients..
27.
2013
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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics..
26.
2012
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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence..
26.
2012
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STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA..
26.
2012
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Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1..
26.
2012
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Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization..
26.
2012
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Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation..
25.
2011
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Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer..
25.
2011
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Neuropilins are positive regulators of Hedgehog signal transduction..
25.
2011
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Genome-wide function of H2B ubiquitylation in promoter and genic regions..
25.
2011
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Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response..
25.
2011
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Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism..
25.
2011
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Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase..
25.
2011
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Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1..
25.
2011
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Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes..
25.
2011
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Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells..
25.
2011
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MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer..
25.
2011
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Sept4/ARTS is required for stem cell apoptosis and tumor suppression..
24.
2010
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PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas..
24.
2010
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Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor..
24.
2010
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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma..
24.
2010
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p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal..
24.
2010
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Pleiotropic role for MYCN in medulloblastoma..
24.
2010
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A midline switch of receptor processing regulates commissural axon guidance in vertebrates..
24.
2010
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Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas..
23.
2009
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Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres..
23.
2009
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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A..
23.
2009
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Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction..
23.
2009
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Molecular orchestration of differentiation and function of regulatory T cells..
23.
2009
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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo..
23.
2009
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AdnAB: a new DSB-resecting motor-nuclease from mycobacteria..
23.
2009
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Mouse models of human AML accurately predict chemotherapy response..
23.
2009
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Modular control of endothelial sheet migration..
22.
2008
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Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events..
22.
2008
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Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b..
22.
2008
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A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size..
22.
2008
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PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo..
22.
2008
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The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends..
22.
2008
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Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage..
22.
2008
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Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing..
21.
2007
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Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions..
21.
2007
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Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome..
21.
2007
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Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization..
21.
2007
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Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression..
20.
2006
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Full and partial genome-wide assembly and disassembly of the yeast transcription machinery in response to heat shock..
20.
2006
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Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors..
20.
2006
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Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells..
19.
2005
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Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes..
19.
2005
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Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization..
18.
2004
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Reprogramming of a melanoma genome by nuclear transplantation..
18.
2004
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The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer..
17.
2003
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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E..
16.
2002
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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes..
15.
2001
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Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival..
15.
2001
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Dynamic association of capping enzymes with transcribing RNA polymerase II..
14.
2000
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SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain..
13.
1999
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Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells..
13.
1999
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A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice..
12.
1998
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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes..
12.
1998
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CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis..
12.
1998
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SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III..
12.
1998
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Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination..
12.
1998
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Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation..
11.
1997
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Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice..
11.
1997
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SKN-1 domain folding and basic region monomer stabilization upon DNA binding..
11.
1997
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Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2..
10.
1996
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Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys..
10.
1996
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c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism..
9.
1995
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Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability..
9.
1995
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Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity..
8.
1994
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Activity of Wnt-1 as a transmembrane protein..
7.
1993
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Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA)..
7.
1993
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Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression..
7.
1993
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Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification..
7.
1993
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Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex..
5.
1991
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Transcription from a TATA-less promoter requires a multisubunit TFIID complex..
5.
1991
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SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src..
4.
1990
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ski can cause selective growth of skeletal muscle in transgenic mice..
4.
1990
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A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B..
4.
1990
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A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator..
4.
1990
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Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei..
3.
1989
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A nucleoprotein complex mediates the integration of retroviral DNA..
3.
1989
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Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.
2016
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Migratory neighbors and distant invaders: tumor-associated niche cells.
2008
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Malignant astrocytic glioma: genetics, biology, and paths to treatment.
2007
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Opportunities and challenges in the development of kinase inhibitor therapy for cancer.
2003
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Stem cells in the skin: waste not, Wnt not.
2003
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Regulation of HIV and HTLV gene expression.
1988
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Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic.
2022
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The roles and regulation of MDM2 and MDMX: it is not just about p53.
2021
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Induced pluripotency: history, mechanisms, and applications.
2010
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