Genes & development

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Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. 2023
An integrated SAGA and TFIID PIC assembly pathway selective for poised and induced promoters.. 36. 2022
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding. 2022
Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. 2021
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas.. 35. 2021
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.. 34. 2020
Recurrent SRSF2 mutations in MDS affect both splicing and NMD.. 34. 2020
Regulation of histone methylation by automethylation of PRC2.. 33. 2019
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.. 33. 2019
Endoreduplication of the mouse genome in the absence of ORC1.. 32. 2018
PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.. 32. 2018
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.. 32. 2018
Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming.. 31. 2017
Dynamic assembly and activation of estrogen receptor α enhancers through coregulator switching.. 31. 2017
Hormone-dependent control of developmental timing through regulation of chromatin accessibility.. 31. 2017
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.. 30. 2016
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.. 30. 2015
Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.. 29. 2015
Molecular mechanisms of ribosomal protein gene coregulation.. 29. 2015
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.. 28. 2014
Two waves of de novo methylation during mouse germ cell development.. 28. 2014
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.. 28. 2014
How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes.. 28. 2014
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.. 28. 2014
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging.. 28. 2014
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.. 28. 2014
A modular and flexible ESC-based mouse model of pancreatic cancer.. 28. 2014
Induction of sarcomas by mutant IDH2.. 27. 2013
Chaperone-mediated autophagy degrades mutant p53.. 27. 2013
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.. 27. 2013
Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.. 27. 2013
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.. 27. 2013
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.. 26. 2012
The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.. 26. 2012
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.. 26. 2012
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.. 26. 2012
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.. 26. 2012
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation.. 25. 2011
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.. 25. 2011
Neuropilins are positive regulators of Hedgehog signal transduction.. 25. 2011
Genome-wide function of H2B ubiquitylation in promoter and genic regions.. 25. 2011
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.. 25. 2011
Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism.. 25. 2011
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.. 25. 2011
Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.. 25. 2011
Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.. 25. 2011
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells.. 25. 2011
MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer.. 25. 2011
Sept4/ARTS is required for stem cell apoptosis and tumor suppression.. 24. 2010
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.. 24. 2010
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.. 24. 2010
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.. 24. 2010
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.. 24. 2010
Pleiotropic role for MYCN in medulloblastoma.. 24. 2010
A midline switch of receptor processing regulates commissural axon guidance in vertebrates.. 24. 2010
Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas.. 23. 2009
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.. 23. 2009
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.. 23. 2009
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.. 23. 2009
Molecular orchestration of differentiation and function of regulatory T cells.. 23. 2009
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.. 23. 2009
AdnAB: a new DSB-resecting motor-nuclease from mycobacteria.. 23. 2009
Mouse models of human AML accurately predict chemotherapy response.. 23. 2009
Modular control of endothelial sheet migration.. 22. 2008
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.. 22. 2008
Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.. 22. 2008
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size.. 22. 2008
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.. 22. 2008
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends.. 22. 2008
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.. 22. 2008
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.. 21. 2007
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.. 21. 2007
Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome.. 21. 2007
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization.. 21. 2007
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.. 20. 2006
Full and partial genome-wide assembly and disassembly of the yeast transcription machinery in response to heat shock.. 20. 2006
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.. 20. 2006
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.. 19. 2005
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.. 19. 2005
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.. 18. 2004
Reprogramming of a melanoma genome by nuclear transplantation.. 18. 2004
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.. 17. 2003
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.. 16. 2002
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.. 15. 2001
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.. 15. 2001
Dynamic association of capping enzymes with transcribing RNA polymerase II.. 14. 2000
SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain.. 13. 1999
Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.. 13. 1999
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.. 12. 1998
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.. 12. 1998
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.. 12. 1998
SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.. 12. 1998
Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination.. 12. 1998
Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation.. 11. 1997
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.. 11. 1997
SKN-1 domain folding and basic region monomer stabilization upon DNA binding.. 11. 1997
Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.. 10. 1996
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.. 10. 1996
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.. 9. 1995
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.. 9. 1995
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.. 8. 1994
Activity of Wnt-1 as a transmembrane protein.. 7. 1993
Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).. 7. 1993
Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.. 7. 1993
Rapid transcriptional autoregulation of a yeast metalloregulatory transcription factor is essential for high-level copper detoxification.. 7. 1993
Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.. 5. 1991
Transcription from a TATA-less promoter requires a multisubunit TFIID complex.. 5. 1991
SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src.. 4. 1990
ski can cause selective growth of skeletal muscle in transgenic mice.. 4. 1990
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.. 4. 1990
A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator.. 4. 1990
Developmental modulation of protein binding to beta-globin gene regulatory sites within chicken erythrocyte nuclei.. 3. 1989
A nucleoprotein complex mediates the integration of retroviral DNA.. 3. 1989
Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis. 2016
Migratory neighbors and distant invaders: tumor-associated niche cells. 2008
Malignant astrocytic glioma: genetics, biology, and paths to treatment. 2007
Opportunities and challenges in the development of kinase inhibitor therapy for cancer. 2003
Stem cells in the skin: waste not, Wnt not. 2003
Regulation of HIV and HTLV gene expression. 1988
mTORC1, the maestro of cell metabolism and growth. 2024
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic. 2022
The roles and regulation of MDM2 and MDMX: it is not just about p53. 2021
Induced pluripotency: history, mechanisms, and applications. 2010

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