National Cancer Institute Funding Organization

Research

awards grant

• "DNMT and TET1 reprogramming as a targetable mechanism of resistance in advanced prostate cancer"
• "Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis"
• (PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment
• (PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment - SUPPLEMENT COST EXTENSION
• (PQ1) Adaptive immune and microbial mechanisms regulating Lynch syndrome penetrance
• 5th Annual International Symposium: Improving Breast Cancer Management and Outcomes
• A Digital Twin for rectal cancer to guide adaptive radiotherapy
• Active Contrast Encoding MRI for Breast Cancer
• An engineered bacterial reporter gene fusion for radiotheranostics
• An urinary drug disposing approach for treatment of bladder Cancer
• Application of 4D proteomics and super-resolution microscopy in extracellular vesicle and particle-borne biomarker discovery for early pancreatic cancer detection
• B cell determinants of EBV latency
• Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)
• CAP-IT Center for LNP RNA Immunoprevention
• CAR T Cells for Advanced Thyroid Cancer
• CD 1530, an RAR Gamma Agonist for Oral Cavity Squamous Cell Carcinoma Prevention
• Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation
• Cancer Pharmacology
• Center for SOcial CApital (SOCA): Promoting Multigenerational Health
• Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
• Cholesterol Metabolism in Mesenchymal Colorectal Cancer
• Chromatin''s Role in Repair of Radiation-induced Damage
• Collaborative genomic alterations and transcriptional control in prostate cancer
• Combination Therapies Targeting Insulin Signaling in Endometrial Cancer
• Computational and experimental methods for scalable identification of oncogenic non-coding regions
• Contributions of tumor molecular subtypes to prostate cancer racial disparities
• Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer
• Copper-Mediated Metabolic Reprogramming And ECM Alterations In TNBC Metastasis
• Culturally Competent Communication Intervention to Improve Latinos'' Engagement in Advance Care Planning
• Culture of tumor versus normal cells
• Customized nanofibers with preferential lung-targeting properties for treating metastatic pulmonary tumors
• DOTA-based pre-targeting of alpha emitters
• Defining Epidrivers of CLL Evolution in Response to Targeted Therapy
• Defining host-microbiota interactions during colorectal cancer and immune checkpoint blockade
• Defining novel mechanisms of microbiota in regulating anti-tumor responses
• Defining the epigenetic landscape and therapeutic vulnerabilities of Richter''s syndrome in CRISPR-based mouse models
• Delirium in Children Undergoing Hematopoietic Stem Cell Transplants
• Differential role of different NAD+ kinase Isoforms in melanoma metastasis
• Diffusion MRI of Treatment Response for De-escalation of Radiation Therapy
• Discovery of a stem cell driving breast cancer spine metastases
• Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem
• Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer
• Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis
• Dynamics of Immune Response in Irradiated Rectal Cancer
• ER stress-driven IRE1a-XBP1 signaling in lung cancer
• ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate Cancer
• Effectiveness and implementation of a decision support tool to improve surgical decision making in young women with breast cancer
• Elucidating the Role of MALAT1 Somatic Driver Mutations in Colorectal Cancer
• Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche
• Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection
• Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
• Exploiting tumor metabolism to optimize T cell therapy
• Exploiting tumor metabolism to optimize T cell therapy
• Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy
• Gradient-Echo Spectroscopic Imaging Study of Saturated Fat and Breast Cancer
• Harnessing oral acetate supplementation to enhance anti-tumor immunity
• Identifying molecular vulnerabilities of ALT-dependent cancers
• Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
• Imaging-Guided Fine tuning of CAR T Cell Affinity to Limit T Cell Cytotoxicity to Tumor Antigen
• Immunometabolic Programs Controlled by ER Stress in Cancer
• Immunoregulatory role of lung-resident club cell factors in lung cancer
• Immunosuppressive Programs Driven by IRE1 signaling in ovarian cancer
• In Vivo Base Editing for Precision Oncology Models
• In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound
• Innate lymphoid cell regulation of the host-microbiota interactions in cancer
• Innate-like lymphocyte regulation of host-microbiota interactions in cancer
• Intercepting progression from pre-invasive to invasive lung adenocarcinoma
• Intercepting progression from pre-invasive to invasive lung adenocarcinoma
• Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer
• Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLC
• Investigating the non-cell autonomous immune effects of mutant p53 in pancreatic cancer
• Investigating the role of the microbiota in enhancing memory T cell function during caloric restriction to promote melanoma control
• Mechanism-Based Targeting of Mantle Cell Lymphoma
• Mechanisms and functions of N6-methyladenosine (m6A) in cancer
• Mechanisms of epitranscriptomic regulation in cancer
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Mitogenic and Oncogenic Regulation of ERK/RSK Signaling
• Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells
• Molecular Phenotyping and Image-Guidance for Surgical Treatment of High-Risk Prostate Cancer Using Ultrasmall Silica Nanoparticles
• Molecular mechanisms driving mesenchymal colorectal cancer
• Molecular mechanisms driving therapy-induced lineage plasticity
• Neoantigen Vaccination for Lynch Syndrome Immunoprevention
• Next-Gen Oncopathology Program
• Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer
• Novel proteasome inhibitors targeting both beta5 and beta2 subunits for treatment of triple negative breast cancer
• Opioid Treatment of Pain in People with Cancer: Intended and unintended consequences of state policies addressing opioid prescribing
• Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere
• Optimizing the Delivery of Diabetes Management During Breast Cancer Care
• PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint Biomarkers
• PSMA/MR-guided Stereotactic Body Radiotherapy for High Risk Prostate Cancer
• Partnership for Prevention of HPV-Associated Cancers in People Living with HIV: Brazil, Mexico, and Puerto Rico
• Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)
• Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)
• Phosphoinositides and Cancer Metabolism
• Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
• Prediagnostic Exposures, Germline Genetics, And Triple Negative Breast Cancer Mutational And Immune Profiles
• Prediction of interval breast cancer risk using genetic variants
• Preventing follicular lymphoma progression and transformation through precision therapy
• Probing cytosolic nucleic acid sensing pathways in cancer
• Propionate metabolism and cancer
• Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)
• Receptor for hyaluronan-mediated motility isoform B (RHAMM B) in Pancreatic Cancer Metastasis
• Robust and Interpretable Multimodal Machine Learning Models for Diagnosis and Prognosis of Prostate Cancer
• Role of BCL10 somatic mutations in lymphomagenesis and response to BCR-targeted therapies
• Role of FAP-positive cells in immune response to irradiated glioblastoma
• Role of chromatin remodeling complex BAF in immunity and lymphoma
• Role of novel onco-histone mutations in B-cell malignancies
• Role of the CD44/Hyaluronan axis in mesenchymal prostate cancer
• Role of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approach
• Role of the stromal microenvironment in B-cell lymphoma progression and immune escape
• Role of the stromal microenvironment in B-cell lymphoma progression and immune escape
• SAMBAI: Societal, Ancestry and Molecular Biology Analyses of Inequalities
• Single-cell dissection of cellular programs driving diffuse glioma evolution
• Small molecule inhibitors of Slit2/Robo signaling as novel therapeutics for glioblastoma
• Structural Racism and Cardiovascular Outcomes Among Cancer Survivors
• Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells
• Systemic regulation of metastasis
• Targeting APOBEC3A-induced genetic heterogeneity and drug resistance in bladder cancer
• Targeting BRCA1/2-deficient cancers with folate and vitamin C
• Targeting Epigenetic Circuits in B-Cell Lymphomas
• Targeting Latency Switch in EBV+ Lymphomas
• Targeting MALT1 to Enhance Anti-Lymphoma Immunity and Response to Immunotherapy
• Targeting drivers of tumor heterogeneity to block the progression to neuroendocrine prostate cancer
• Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer
• The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune Response
• The Role of Propionate Metabolism in Non-Small Cell Lung Cancer
• The joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles
• The role of NAGK cysteine deprotonation in nutrient stress and cancer progression
• The role of the mycobiome in cancer
• Therapeutic Targeting of SIRT3 for Aggressive and Refractory Lymphomas
• To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models
• Tumor selective inhibition of the WNT pathway
• UBR5''s Mechanisms of Action in Tumorigenesis and Immunoregulation
• Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging
• Ultrasmall particle-based solutions for inducing ferroptosis and improving anti-tumor immune responses in cancer
• Upstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancer