Brain and Mind Research Academic Department

Research

administers grant

• 18F-PU-AD epichaperome PET to characterize and diagnose AD and ADRD
• A Circuit Mechanism for the Development of Cortico-cortical Connectivity
• A novel gene therapy approach to prevent alpha-synuclein misfolding in multiple system atrophy
• A three-dimensional tissue model linking tau tangles, abeta and microglial CD33-isoform state to gene- and isoform-expression dysregulation.
• Alzheimer Pathology and Neurovascular Dysfunction
• ApoE4, neurovascular injury and cognitive impairment
• Assessment of early somatosensory impairment in the KIKO mouse model of Friedreich''s ataxia
• Biopharma Agreement with Astoria Biologica
• CHCHD10 frontotemporal dementia, molecular mechanisms and therapeutic strategies
• Cell & non-cell autonomous effects of frataxin deficiency in FA pathophysiology
• Central Processing of Visual Information
• Central Processing of Visual Information
• Central thalamic deep brain stimulation to regulate arousal and cognition
• Changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for synucleinopathies
• Contribution of G Protein Coupled Estrogen Receptor to Changes in Hypothalamic Plasticity and Hypertension Susceptibility in Mice with Accelerated Ovarian Failure
• Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function
• Determining the role of Glucose transporter 1 in neural development and disease
• Dietary sodium, neurovascular dysfunction and cerebrovascular risk
• Dissecting STXBP1 dysfunction in a novel mouse model of STXBP1 Encephalopathies
• Elucidate the Roles of Alzheimer''s Disease Variants in Gene Expression and AD Phenotypes
• Elucidating the Cell-Type Specific Neuroprotective Mechanisms in the APOE3 Christchurch Mutation in Alzheimer''s Disease
• Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer''s disease
• Ethnicity-Associated, Differential Cns Demyelinating Autoimmune Disease Severity: Reconciling Identity, Ancestry And Neurotoxic Antibody Response
• Function of Fixational Instability During Natural Viewing
• GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum Disorders
• Genetic and metabolic strategies for mutant CHCHD10 neuromuscular disorders
• Gut Immunity, Neurovascular dysregulation and Cognitive Impairment
• Harboring the Initial Trigger of Multiple Sclerosis
• Hypertension, tau and neurodegeneration
• Identifying the downstream targets of neural FOXP1
• Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
• Integrative Single Cell Isoform And Chromatin Accessibility Mapping Of Chronic Opioid Exposure In Cognitive Brain Areas In HIV
• Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
• Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memories
• Investigating the role of cGAS signaling and microglial senscence in tauopathy
• Investigating the role of cGAS signaling and microglial senscence in tauopathy
• JSMF Covid-19 Consortium for Recovery of Consciousness
• Linking tau proteostasis with neuronal activity in FTD
• Metabolic landscape and mitochondrial ROS balance in brain ischemia/reperfusion
• Metabolic remodeling of skeletal muscle in mitochondrial myopathies
• Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
• Mitochondrial Integrated Stress Response In Neurological Diseases
• Mitochondrial and Metabolic Dysfunction in Age-Related Neurodegeneration
• Mitochondrial proton leak and neonatal brain injury
• Modeling pathological Tau propagation in human brain cells in vivo
• Molecular and cellular mechanisms of cardiac fibrosis in Friedreich ataxia
• Molecular mechanisms and effects of Alzheimer''s-related lipid dysregulation
• Molecular mechanisms and effects of Alzheimer’s related lipid dysregulation in astrocytes
• Multiome measurements connecting transcription start sites at single-nucleotide resolution, DNA methylation and open chromatin status to splicing outcome across single cells in health and disease
• Myelin Repair Foundation
• Neural Mechanism for the assembly of GABAergic in the cerebral cortex
• NeuroNex: From Odor to Action:Discovering Principles of Olfactory-Guided Natural Behavior
• Neurovascular and neuronal network dysfunction in tauopathy mouse models
• Postnatal development of the cerebellar circuitry in the KIKO mouse model of Friedreich''s ataxia
• Role of fixational eye movements and saccades in processing spatial information in V1-V2-V4 networks
• Role of perivascular macrophages in ApoE4-induced neurovascular dysfunction
• Role of prohibitin nitrosylation in its neuroprotective functions
• Selective frataxin deficiency in glial cells in vivo in novel mouse models of Friedreich''s ataxia
• Stalled capillary flow: a novel mechanism for hypoperfusion in Alzheimer disease
• Stroke Impact (Stroke Immune Mediated Pathways and Cognitive Trajectory)
• Synaptic vesicle changes in synucleinopathies
• Targeting GDF15-GFRAL signaling in mitochondrial myopathies
• Tau proteostasis by chaperone-complexes in tauopathies including Alzheimer''s disease
• Tau-induced postsynaptic dysfunction in tauopathy models
• Thalamic stimulation to prevent impaired consciousness in epilepsy
• The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function
• The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology
• The role of FMN loss by mitochondrial Complex I in neonatal hypoxic-ischemic brain injury
• The role of VAMP2 in alpha-synuclein function and pathology
• The role of dendritic cells in regulating the gut-brain immune axis in ischemic stroke
• Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
• tPA and cerebrovascular regulation in a model of ß-amyloid pathology