Brain and Mind Research Academic Department

Research

administers grant

• 18F-PU-AD epichaperome PET to characterize and diagnose AD and ADRD
• A Circuit Mechanism for the Development of Cortico-cortical Connectivity
• A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system
• A novel gene therapy approach to prevent alpha-synuclein misfolding in multiple system atrophy
• Alzheimer Pathology and Neurovascular Dysfunction
• An in vivo strategy to study the impact of GABRB3 mutations on the development of cortical circuits
• ApoE4, neurovascular injury and cognitive impairment
• Assessment of early somatosensory impairment in the KIKO mouse model of Friedreich''s ataxia
• Astrocyte RNA degradation and cognitive function
• Astrocyte dysfunction in idiopathic autism
• Astrocytic function of the novel ASD-risk gene GIGYF1 in brain development
• BRAIN CONNECTS: The Center for Large-scale Imaging of Neural Circuits (LINC)
• Biopharma Agreement with Astoria Biologica
• CHCHD10 frontotemporal dementia, molecular mechanisms and therapeutic strategies
• CZI DAF
• Calcium communication among intracellular compartments in FA patient-derived cells
• Cell & non-cell autonomous effects of frataxin deficiency in FA pathophysiology
• Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
• Cellular Mechanism of Adult Onset Neuronal Ceroid Lipofuscinosis (ANCL) Caused by Mutations in Cysteine String Protein-Alpha (CSPalpha)
• Central Processing of Visual Information
• Central thalamic deep brain stimulation to regulate arousal and cognition
• Contribution of G Protein Coupled Estrogen Receptor to Changes in Hypothalamic Plasticity and Hypertension Susceptibility in Mice with Accelerated Ovarian Failure
• Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function
• Development of novel genomic approaches for profiling cellular temporal-spatial dynamics of neurogenesis in Aging and Alzheimer''s disease
• Dietary sodium, neurovascular dysfunction and cerebrovascular risk
• Dissecting STXBP1 dysfunction in a novel mouse model of STXBP1 Encephalopathies
• Dissecting immune resilience mechanism in human neuron-microglia chimera model
• Elucidate the Roles of Alzheimer''s Disease Variants in Gene Expression and AD Phenotypes
• Elucidating the Cell-Type Specific Neuroprotective Mechanisms in the APOE3 Christchurch Mutation in Alzheimer''s Disease
• Epilepsy Multiplatform Variant Prediction (EpiMVP)
• Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer''s disease
• Ethnicity-Associated, Differential Cns Demyelinating Autoimmune Disease Severity: Reconciling Identity, Ancestry And Neurotoxic Antibody Response
• Evaluation of a novel human cGAS inhibitor using human iPSC derived models
• Exploring HIV-associated Neurocognitive Disorder (HAND) and HIV Latency at the Single Cell Level in Cerebral Organoids
• Exploring exosomes in neurodevelopmental and neuropsychiatric diseases using brain organoids
• Function of Fixational Instability During Natural Viewing
• GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum Disorders
• Genetic and metabolic strategies for mutant CHCHD10 neuromuscular disorders
• Genetic circuitry governing heart growth and repair
• Genome-wide identification and characterization of Alzheimer''s Disease-associated enhancers
• Global mapping of altered neural circuits in a mouse model of DDX3X mutations
• Gut Immunity, Neurovascular dysregulation and Cognitive Impairment
• HEVOLUTION NETWORK ON SENESCENCE IN AGING
• Harboring the Initial Trigger of Multiple Sclerosis
• High-speed imaging of cortical and white matter microvascular flow in ADRD models
• Hypertension, tau and neurodegeneration
• Identification and development of CD33 inhibitors and pre-RNA splicing modulators
• Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
• In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues
• Insulin resistance and metabolic network remodeling in Alzheimer''s disease: a systems approach
• Integrative Single Cell Isoform And Chromatin Accessibility Mapping Of Chronic Opioid Exposure In Cognitive Brain Areas In HIV
• Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV
• Investigating the Neurobiology of Early Cognitive Impairment
• Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memories
• Investigating the role of cGAS signaling and microglial senscence in tauopathy
• JSMF Covid-19 Consortium for Recovery of Consciousness
• Linking tau proteostasis with neuronal activity in FTD
• Maladaptive Antiviral Pathways In Alzheimer''S Disease
• Mechanisms of anosmia and brain infection in a mouse model of COVID-19
• Metabolic landscape and mitochondrial ROS balance in brain ischemia/reperfusion
• Metabolic origin of oxidative stress injury in brain ischemia/reperfusion
• Metabolic remodeling of skeletal muscle in mitochondrial myopathies
• Methods to optimize the benzofuran and benzothiophene human cGAS inhibitor leads
• Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
• Mitochondrial Integrated Stress Response In Neurological Diseases
• Mitochondrial and Metabolic Dysfunction in Age-Related Neurodegeneration
• Mitochondrial proton leak and neonatal brain injury
• Model and identify genetic modifiers of PSP 4R tauopathies in human neurons
• Model human neuron-microglia interactions in chimera model of PSP and other 4R tauopathies
• Modeling pathological Tau propagation in human brain cells in vivo
• Molecular control of cardiac regenerative potential
• Molecular mechanisms and effects of Alzheimer''s-related lipid dysregulation
• Multiome measurements connecting transcription start sites at single-nucleotide resolution, DNA methylation and open chromatin status to splicing outcome across single cells in health and disease
• Neural Mechanism for the assembly of GABAergic in the cerebral cortex
• NeuroNex: From Odor to Action:Discovering Principles of Olfactory-Guided Natural Behavior
• Neurovascular and neuronal network dysfunction in tauopathy mouse models
• Pathogenic mechanisms and therapeutic strategies for CHCHD10 ALS
• Postdoctoral Fellowship Program in ALZHEIMER''S DISEASE Research
• Postnatal development of the cerebellar circuitry in the KIKO mouse model of Friedreich''s ataxia
• Protective monocytes in cerebral ischemic tolerance
• Rainwater Drug Discovery Grant
• Role of CaMKII-alpha ubiquitination in ischemic stroke
• Role of fixational eye movements and saccades in processing spatial information in V1-V2-V4 networks
• Role of perivascular macrophages in ApoE4-induced neurovascular dysfunction
• Role of prohibitin nitrosylation in its neuroprotective functions
• SRA
• Selective frataxin deficiency in glial cells in vivo in novel mouse models of Friedreich''s ataxia
• Stroke Impact (Stroke Immune Mediated Pathways and Cognitive Trajectory)
• Study of Selective Cell and System Vulnerability in Alzheimer''s Disease
• Synaptic vesicle changes in synucleinopathies
• Targeting maladaptive innate immune response to treat PD
• Tau proteostasis by chaperone-complexes in tauopathies including Alzheimer''s disease
• Tau-induced postsynaptic dysfunction in tauopathy models
• The Alzheimer''s Disease Tau Platform Clinical Trial
• The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function
• The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology
• The role of FMN loss by mitochondrial Complex I in neonatal hypoxic-ischemic brain injury
• The role of VAMP2 in alpha-synuclein function and pathology
• The role of dendritic cells in regulating the gut-brain immune axis in ischemic stroke
• Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
• Uncovering the role of astrocyte RNA regulation in the central nervous system
• Understanding Genetic Complexity in Spina Bifida
• cGAS inhibitors for Alzheimer''s disease treatment
• tPA and cerebrovascular regulation in a model of ß-amyloid pathology