Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis. Academic Article uri icon

Overview

abstract

  • Herein we review the evidence that neocortical projection neurons and interneurons are derived from distinct regions within the telencephalon. While neocortical projection neurons are derived from the ventricular zone of the neocortex, neocortical interneurons appear to be derived from the germinal zone of the basal ganglia. These interneurons follow a tangential migratory pathway from the ganglionic eminences to the cortex. Interneurons of the olfactory bulb follow a distinct tangential migration from the basal ganglia. The Dlx homeobox genes, which are essential for basal ganglia differentiation, are also required for the development of neocortical and olfactory bulb interneurons. Furthermore, evidence is presented that retroviral-mediated expression of DLX2 in neocortical cells can induce GABAergic interneuron differentiation.

publication date

  • September 1, 1999

Research

keywords

  • Cell Movement
  • Homeodomain Proteins
  • Interneurons
  • Neocortex

Identity

Scopus Document Identifier

  • 0032826751

PubMed ID

  • 10498283

Additional Document Info

volume

  • 9

issue

  • 6