Chemical modification of nodulisporic acid A: preliminary structure-activity relationships. Academic Article uri icon

Overview

abstract

  • Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.

authors

  • Meinke, Peter T
  • Ayer, M B
  • Colletti, S L
  • Li, Chunshi
  • Lim, Julie
  • Ok, Dong
  • Salva, Steve
  • Schmatz, D M
  • Shih, T L
  • Shoop, W L
  • Warmke, L M
  • Wyvratt, M J
  • Zakson-Aiken, Michelle
  • Fisher, M H

publication date

  • October 16, 2000

Research

keywords

  • Indoles
  • Insecticides

Identity

Scopus Document Identifier

  • 0034675742

PubMed ID

  • 11055358

Additional Document Info

volume

  • 10

issue

  • 20