Central venous catheters are associated with the vast majority of nosocomial, catheter-related bloodstream infections (CR-BSI). Despite identification of multiple effective methods for preventing CR-BSI, it remains an important clinical problem. Catheters coated with anti-infective substances, such as chlorhexidine and silver sulfadiazine or rifampin and minocycline, have shown promising results in recent clinical trials, but confirmatory studies by different investigators are still needed. Concern has also been raised about widespread use of clinically important antibiotics on catheter surfaces, which may promote the development of antibiotic resistance. More accurate and cost-effective methods of diagnosing CR-BSI are desirable. Recent studies have evaluated endoluminal brush sampling and differential blood culture growth rates, which may provide acceptable accuracy without requiring removal of long-dwelling catheters, but the accuracy of these techniques needs to be confirmed in other studies.
