Effect of transjugular intrahepatic portosystemic shunt on thrombocytopenia associated with cirrhosis. Academic Article uri icon

Overview

abstract

  • Thrombocytopenia is a frequent complication of cirrhosis. Its pathogenesis is not well known, but it has been suggested that splenic congestion induced by portal hypertension may be a major contributory factor. However, the available data regarding the effect of portal decompression either by surgical shunts or transjugular intrahepatic portosystemic shunt (TIPS) on peripheral platelet count in cirrhotics is conflicting. We studied the effects of TIPS on platelet count and mean platelet volume, following a successful TIPS placement. The platelet count had a tendency to decrease but was not statistically significant (120,100 +/- 72,100/mm3 before TIPS vs 99,800 +/- 51,400/mm3 after TIPS). The mean platelet volume remained essentially unchanged (9.8 +/- 1.5 fL before TIPS and 9.9 +/- 1.5 fL after TIPS). These results confirm that TIPS has an unpredictable effect on platelet count in cirrhotic patients with thrombocytopenia. The lack of a consistent increase in the peripheral mean platelet volume following TIPS placement suggests that TIPS is unable to significantly enhance the release of platelets sequestered in the splenic compartment in portal hypertension.

publication date

  • October 1, 2000

Research

keywords

  • Liver Cirrhosis
  • Platelet Count
  • Portasystemic Shunt, Transjugular Intrahepatic
  • Thrombocytopenia

Identity

Scopus Document Identifier

  • 0033732227

PubMed ID

  • 11117569

Additional Document Info

volume

  • 45

issue

  • 10