A Coordinate System for Tumor Identification in Positron Emission Tomography (PET) Imaging. Academic Article uri icon

Overview

abstract

  • Purpose: PET can be useful in determining the progression of malignant disease over time as well as the response to therapy. To achieve this, the physician must be able to unambiguously identify and characterize individual tumors among several different scans.Methods: We have developed a coordinate system for identifying individual tumor sites on PET scans, selecting the carina on the transmission scan as a point of origin. Using this system, each tumor is given a set of spherical coordinates that identifies its position: a rho (rho, displacement from carina), a theta (θ, angle between the A-P axis and the tumor), and a phi (φ, angle between the polar axis and the tumor). We tested this method on a patient with metastatic thyroid cancer, who underwent 18FDG and 124I-Iodide PET scans in the same week. This sytem was also used on a patient with metastatic prostate cancer, who had two FDG scans done 7 weeks apart. The patient underwent chemotherapy treatment during this period, and the scans were performed to assess therapy response.Results: The patient with thyroid cancer had a total of 90 tumors, 82 of them identified in the 18FDG scan and 35 in the 124I-Iodide scan, with 27 tumors identified in both. For rho, θ, and φ among the 27 matching pairs of tumors, the mean differences were 6.80 +/- 5 mm, 6.22 +/- 4.54 degrees, and 5.51 +/- 5.81 degrees, respectively. The disparity in coordinate values between corresponding tumors can be explained by the distinctive uptake patterns of the radiopharmaceuticals. The patient with prostate cancer had 9 tumors identifiable in both the pre- and post-therapy scans. The mean differences for rho, θ, and φ among the 9 pairs of tumors were 1.93 +/- 1.65 mm, 6.67 +/- 5.53 degrees, and 2.04 +/- 2.02 degrees, respectively. After thorough analysis, we have determined that corresponding tumors with rho < 15 mm, θ and φ < 15 degrees difference usually indicate a match.Conclusion: This coordinate system facilitates the identification and characterization of individual tumors among multiple scans, thus aiding in both the assessment of diagnostic capabilities of different tracers, and the tracking of tumors following therapy.

publication date

  • July 1, 2000

Identity

PubMed ID

  • 11150744

Additional Document Info

volume

  • 3

issue

  • 4