Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1. Academic Article uri icon

Overview

abstract

  • Apicidin, a natural product recently isolated at Merck, inhibits both mammalian and protozoan histone deacetylases (HDACs). The conversion of apicidin, a nanomolar inhibitor of HDACs, into a series of side-chain analogues that display picomolar enzyme affinity is described within this structure-activity study.

publication date

  • January 22, 2001

Research

keywords

  • Antiprotozoal Agents
  • Histone Deacetylase Inhibitors
  • Peptides, Cyclic

Identity

Scopus Document Identifier

  • 0035931503

PubMed ID

  • 11206438

Additional Document Info

volume

  • 11

issue

  • 2