Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: The goal of this study was to specifically estimate the effectiveness of platelet releasate, a widely available treatment administered by a proprietary group of wound care centers (WCCs) for the treatment of diabetic neuropathic foot ulceration. RESEARCH DESIGN AND METHODS: Treatment effectiveness was estimated in a retrospective cohort study controlling for treatment selection bias using logistic regression-derived propensity scores. RESULTS: Platelet releasate was more effective than standard care. The relative risk for a wound to heal after treatment with platelet releasate compared with standard care at a WCC varied from 1.14 (95% CI 1.03-1.27) to 1.59 (1.49-1.70). The effect was greatest in those with the most severe wounds, i.e., large wounds that affect deeper anatomical structures. CONCLUSIONS: Within the limitations of the ability of propensity score analysis to control for selection bias, platelet releasate is more effective than standard therapy. This effect is more pronounced in more severe wounds. Unfortunately, severe wounds have not been evaluated in randomized clinical trials of new interventions. We encourage the inclusion of these patients in future trials.

publication date

  • March 1, 2001

Research

keywords

  • Blood Platelets
  • Diabetic Foot
  • Diabetic Neuropathies
  • Growth Substances
  • Platelet-Derived Growth Factor
  • Wound Healing

Identity

Scopus Document Identifier

  • 0035092184

PubMed ID

  • 11289472

Additional Document Info

volume

  • 24

issue

  • 3