Human receptors for immunoglobulin G: key elements in the pathogenesis of rheumatic disease. Review uri icon

Overview

abstract

  • The structural diversity of Fc gammaR provides a mechanism by which IgG can elicit a broad range of cell responses. Fc gammaR vary in their affinity for IgG, their preference for IgG subclasses, the cell types in which they are expressed, and the intracellular signals which they elicit--stimulatory or inhibitory. Expansion in our knowledge of structure-function relationships among Fc gammaR has identified them as heritable risk factors for disease susceptibility and valuable targets for therapeutic modulation of the immune system.

publication date

  • April 1, 2001

Research

keywords

  • Receptors, IgG
  • Rheumatic Diseases

Identity

Scopus Document Identifier

  • 0035046581

PubMed ID

  • 11315912

Additional Document Info

volume

  • 44

issue

  • 4