A formal total synthesis of racemic sesquiterpenoid sativene. Academic Article uri icon

Overview

abstract

  • Several key reactions involving intramolecular cyclization, Grignard reaction, and ionic hydrogenation have been employed in a formal synthesis of sativene. The synthesis affords 3-isopropyl-6-methyltricyclo[4.4.0.0(2,8)]decan-7-one, 12, McMurry's penultimate precursor to sativene, in 28% overall yield in eight steps starting with the commercially available racemic Wieland--Miescher ketone.

publication date

  • April 1, 2001

Research

keywords

  • Sesquiterpenes

Identity

Scopus Document Identifier

  • 0035013044

PubMed ID

  • 11325217

Additional Document Info

volume

  • 64

issue

  • 4