Retinoids have been investigated for their effects in the prevention and treatment of cancer. Scores of synthetic and natural ligands suppress growth and normalize differentiation of cells in vitro and in vivo. The molecular mechanisms of these activities are being elucidated with the goal of improving the therapeutic index. Here we summarize recent advances in the understanding of retinoid signaling via nuclear receptors, corepressors, and coactivators and review the effects of retinoid treatment on cell-cycle control elements and cyclin proteins.
