Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles.
Academic Article
Overview
abstract
[reaction--see text] The semisynthetic conversion of nodulisporic acid A (1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal activity and pharmacokinetic profile relative to the natural product.
