NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Academic Article uri icon

Overview

abstract

  • The transcription factor NF-kappa B regulates gene expression involved in cell growth and survival and has been implicated in progression of hormone-independent breast cancer. By expressing a dominant-active form of mitogen-activated protein kinase kinase kinase 1, by exposure to tumor necrosis factor alpha, or by overexpression of p50/p65, we show that NF-kappa B activates a transcription regulatory element of the prostate-specific antigen (PSA)-encoding gene, a marker for prostate cancer development, treatment, and progression. By DNase I footprinting, we identified four NF-kappa B binding sites in the PSA core enhancer. We also demonstrate that androgen-independent prostate cancer xenografts have higher constitutive NF-kappa B binding activity than their androgen-dependent counterparts. These results suggest a role of NF-kappa B in prostate cancer progression.

publication date

  • April 1, 2002

Research

keywords

  • NF-kappa B
  • Prostate-Specific Antigen
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC133743

Scopus Document Identifier

  • 0036196320

PubMed ID

  • 11909978

Additional Document Info

volume

  • 22

issue

  • 8