The interplay of dendritic cell subsets in systemic lupus erythematosus. Review uri icon

Overview

abstract

  • Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

publication date

  • October 1, 2002

Research

keywords

  • Autoimmune Diseases
  • Dendritic Cells
  • Lupus Erythematosus, Systemic

Identity

Scopus Document Identifier

  • 0036380887

PubMed ID

  • 12225385

Additional Document Info

volume

  • 80

issue

  • 5