Tissue reactivity of anti-Leu19. Academic Article uri icon

Overview

abstract

  • Monoclonal antibody anti-Leu19, is a marker of natural killer cells. Since reactivity between anti-Leu7, another natural killer cell marker, and small cell neuroendocrine carcinomas has been described, we evaluated the reactivity of anti-Leu19 in 92 neuroendocrine tumours. Frozen sections in each case were immunostained using the avidin-biotin-peroxidase complex method with monoclonal anti-Leu19. We found Leu19 expression in 93% of the cases. We also evaluated 149 other tumours, including adenocarcinomas, undifferentiated large cell carcinomas, lymphomas, melanomas and soft tissue tumours. We found Leu19 expression in 36% (by liberal interpretative criteria), or 29% (by conservative interpretative criteria) of these cases. Thus, while anti-Leu19 appears to be a sensitive marker for neuroendocrine tumours, a lack of specificity limits its practical application in diagnostic histopathology.

publication date

  • December 1, 1992

Research

keywords

  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • Endocrine Gland Neoplasms
  • Neoplasms, Nerve Tissue
  • Neurosecretory Systems

Identity

Scopus Document Identifier

  • 0026745569

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2559.1992.tb00445.x

PubMed ID

  • 1281805

Additional Document Info

volume

  • 21

issue

  • 6