Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth. Academic Article uri icon

Overview

abstract

  • Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.

publication date

  • March 16, 1992

Research

keywords

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Isoantibodies
  • Membrane Glycoproteins
  • Neurites
  • Retinal Ganglion Cells

Identity

Scopus Document Identifier

  • 0026561642

PubMed ID

  • 1352632

Additional Document Info

volume

  • 137

issue

  • 1