Serum anti-SS-B/La and IgA rheumatoid factor are markers of salivary gland disease activity in primary Sjögren's syndrome. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To identify serologic markers of salivary gland disease activity in 43 patients with primary Sjögren's syndrome. METHODS: Comparison of salivary gland biopsies (focus scores) and flow rates with serum concentrations of IgA and IgM rheumatoid factor (RF), total serum IgG, serum anti-SS-B/La antibodies, and the erythrocyte sedimentation rate. RESULTS: Serum anti-SS-B/La antibody levels correlated with focus scores (rs = 0.477, P < 0.0025). Serum IgA-RF concentrations correlated inversely with stimulated parotid gland salivary flow rates (rs = -0.394, P < 0.01). CONCLUSION: Measuring serum levels of anti-SS-B/La and IgA-RF would be useful when monitoring salivary responses in therapeutic trials, especially in patients with minimal salivary function.

publication date

  • November 1, 1992

Research

keywords

  • Antibodies, Antinuclear
  • Immunoglobulin A
  • Rheumatoid Factor
  • Salivary Gland Diseases
  • Sjogren's Syndrome

Identity

Scopus Document Identifier

  • 0026499331

PubMed ID

  • 1445455

Additional Document Info

volume

  • 35

issue

  • 11