Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties. Academic Article uri icon

Overview

abstract

  • The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.

publication date

  • October 20, 2003

Research

keywords

  • Cytomegalovirus
  • Endopeptidases
  • Flavins
  • Protease Inhibitors
  • Pyrimidines

Identity

Scopus Document Identifier

  • 0141517088

PubMed ID

  • 14505653

Additional Document Info

volume

  • 13

issue

  • 20