Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study). Academic Article uri icon

Overview

abstract

  • In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5 degrees C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.

publication date

  • March 1, 2004

Research

keywords

  • Angioplasty, Balloon, Coronary
  • Hypothermia, Induced
  • Myocardial Infarction
  • Myocardial Reperfusion Injury

Identity

Scopus Document Identifier

  • 10744224013

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2003.11.038

PubMed ID

  • 14996598

Additional Document Info

volume

  • 93

issue

  • 5