Effectiveness of prostaglandin E1 in relieving obstruction in coarctation of the aorta without opening the ductus arteriosus. uri icon

Overview

abstract

  • The two main theories regarding the pathogenesis of coarctation of the aorta are the Skodaic hypothesis of ductal tissue constricting the aorta at the level of the insertion of the ductus arteriosus and the flow theory of decreased ascending aortic blood flow in the fetus, which results in associated isthmic narrowing and a localized shelf. To document that ectopic ductal tissue constriction can cause coarctation of the aorta in the absence of a patent ductus arteriosus, we report three cases of infants presenting with critical coarctation who responded to prostaglandin E1 infusion without opening the ductus arteriosus.

publication date

  • January 1, 2004

Research

keywords

  • Alprostadil
  • Aortic Coarctation
  • Arterial Occlusive Diseases

Identity

Scopus Document Identifier

  • 0942287078

Digital Object Identifier (DOI)

  • 10.1007/s00246-003-0549-5

PubMed ID

  • 15043008

Additional Document Info

volume

  • 25

issue

  • 1