Costimulatory molecules and T-cell-B-cell interactions. Review uri icon

Overview

abstract

  • This article focuses on activating and inhibiting costimulatory signals that are delivered to the T cell from antigen-presenting cells, mediating and modulating T-cell clonal expansion and development of effector functions, as well as costimulatory signals that are delivered by activated T cells to interacting target cells. The coordinated expression and interaction of these molecules regulates responses to foreign antigens and avoidance of response to self-antigens. Knowledge of the structure and function of these costimulatory molecules can be used to manipulate immune function and inhibit autoimmunity and inflammation in the setting of disease.

publication date

  • February 1, 2004

Research

keywords

  • B-Lymphocytes
  • Cell Communication
  • Lymphocyte Activation
  • Membrane Glycoproteins
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 1242272832

PubMed ID

  • 15061574

Additional Document Info

volume

  • 30

issue

  • 1