Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
Academic Article
Overview
abstract
Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition.
