Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus.
Academic Article
Overview
abstract
The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC50s<0.1 microM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus.
