mTOR, translational control and human disease. Review uri icon

Overview

abstract

  • Many human diseases occur when the precise regulation of cell growth (cell mass/size) and proliferation (rates of cell division) is compromised. This review highlights those human disorders that occur as a result of inappropriate cellular signal transduction through the mammalian target of rapamycin (mTOR), a major pathway that coordinates proper cell growth and proliferation by regulating ribosomal biogenesis and protein translation. Recent studies reveal that the tuberous sclerosis complex (TSC)-1/2, PTEN, and LKB1 tumor suppressor proteins tightly control mTOR. Loss of these tumor suppressors leads to an array of hamartoma syndromes as a result of heightened mTOR signaling. Since mTOR plays a pivotal role in maintaining proper cell size and growth, dysregulation of mTOR signaling results in these benign tumor syndromes and an array of other human disorders.

publication date

  • December 31, 2004

Research

keywords

  • Disease
  • Protein Biosynthesis
  • Protein Kinases
  • Signal Transduction

Identity

Scopus Document Identifier

  • 12344262762

PubMed ID

  • 15659337

Additional Document Info

volume

  • 16

issue

  • 1