Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain. Academic Article uri icon

Overview

abstract

  • A series of new voltage-gated sodium channel blockers were prepared based on the screening lead succinic diamide BPBTS. Replacement of the succinimide linker with the more rigid cyclic 1,2-trans-diamide linker was well tolerated. N-Methylation on the biphenylsulfonamide side of the amide moiety significantly reduced the clearance rate in rat pharmacokinetic studies.

publication date

  • April 1, 2005

Research

keywords

  • Amides
  • Cyclopentanes
  • Pain
  • Sodium Channel Blockers

Identity

Scopus Document Identifier

  • 20144383383

PubMed ID

  • 15780630

Additional Document Info

volume

  • 15

issue

  • 7