Selective PPARgamma modulators with improved pharmacological profiles. Academic Article uri icon

Overview

abstract

  • A series of metabolically robust N-benzyl-indole selective PPARgamma modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARgammaMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARgamma full agonists.

publication date

  • May 16, 2005

Research

keywords

  • Indoles
  • PPAR gamma

Identity

Scopus Document Identifier

  • 20944436063

PubMed ID

  • 15863293

Additional Document Info

volume

  • 15

issue

  • 10