Successful treatment of malignant melanoma in situ with topical 5% imiquimod cream. uri icon

Overview

abstract

  • BACKGROUND: Current treatment recommendations for malignant melanoma in situ include surgical excision with at least 0.5 cm margins. On the head or neck, obtaining adequate surgical margins for melanoma can be challenging and often disfiguring. In addition, some elderly patients may not be good surgical candidates and may request less aggressive interventions. METHODS: We report herein three cases of malignant melanoma in situ on the face treated with topical imiquimod cream. RESULTS: Complete regression of malignant melanoma in situ was observed on treatment with 5% topical imiquimod cream. The varied treatment regimens, rationale for using imiquimod rather than performing surgery, and the possible mechanisms of action are discussed. CONCLUSIONS: Topical imiquimod can be used successfully for the treatment of malignant melanoma in situ on the face.

publication date

  • May 1, 2005

Research

keywords

  • Aminoquinolines
  • Antineoplastic Agents
  • Facial Neoplasms
  • Melanoma
  • Skin Neoplasms

Identity

Scopus Document Identifier

  • 18844457392

PubMed ID

  • 15869545

Additional Document Info

volume

  • 44

issue

  • 5