MR imaging guidance has great potential to direct the management of diagnostic and therapeutic procedures performed in the musculoskeletal region. To take full advantage of this excellent diagnostic tool, radiologists should also embrace the minimally invasive techniques available for MR imaging. This can be achieved by cooperation with clinical colleagues, multidisciplinary integration, and the development of efficient techniques for MR-guided procedures. By combining the excellent ability to recognize pathologic findings and the feasibility of performing interventional procedures, MR imaging is emerging as a powerful tool in diagnosing and treating musculoskeletal neoplasms and in performing minimally invasive procedures, such as spine injections.