Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers. Academic Article uri icon

Overview

abstract

  • The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.

publication date

  • August 23, 2005

Research

keywords

  • Apolipoproteins E
  • Genetic Predisposition to Disease
  • Heterozygote
  • Memory Disorders
  • Sleep Apnea Syndromes

Identity

PubMed ID

  • 16116137

Additional Document Info

volume

  • 65

issue

  • 4